Results 101 to 110 of about 670,134 (326)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Droplet digital polymerase chain reaction for rapid broad‐spectrum detection of bloodstream infections

Microbial Biotechnology, 2020
Summary The droplet digital polymerase chain reaction (ddPCR) is a novel molecular technique that allows rapid quantification of rare target DNA sequences.
Yannick Wouters, Daisy Dalloyaux, Anke Christenhusz, Hennie M. J. Roelofs, Heiman F. Wertheim, Chantal P. Bleeker‐Rovers, René H. teMorsche, Geert J. A. Wanten   +7 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

The indirect impacts of nonpharmacological COVID-19 control measures on other infectious diseases in Yinchuan, Northwest China: a time series study

BMC Public Health, 2023
Background Various nonpharmaceutical interventions (NPIs) against COVID-19 continue to have an impact on socioeconomic and population behaviour patterns.
Weichen Liu, Ruonan Wang, Yan Li, Shi Zhao, Yaogeng Chen, Yu Zhao   +5 more
doaj   +1 more source

Bats, Coronaviruses, and Deforestation: Toward the Emergence of Novel Infectious Diseases?

Frontiers in Microbiology, 2018
Coronaviruses (CoV) were for a long time associated with several major veterinary diseases such as avian infectious coronavirus, calf diarrhea, winter dysentery, respiratory infections (BRD-BCoV) in cattle, SDCV, PEDV, SECD in swine and dog, intestinal ...
A. Afelt, R. Frutos, C. Devaux
semanticscholar   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Infectious Intestinal Diseases and Residential Water Services in Mexico: a Spatial Analysis

AIMS Geosciences, 2017
Infectious intestinal diseases (IID) represent a widespread public health problem in Mexico. The country also faces major challenges with respect to the provision of residential water services (piped water and sewer)—an essential input for hygiene and cleanliness in homes.
Nicholas P. Sisto, Laura Maribel Colima Valadez, Juan Jacob Ayala Gaytán, Ismael Aguilar Barajas   +3 more
openaire   +3 more sources

Prevalence and factors associated with one-year mortality of infectious diseases among elderly emergency department patients in a middle-income country

BMC Infectious Diseases, 2019
BackgroundThis study aimed to determine the prevalence of infectious diseases and risk factors for one-year mortality in elderly emergency department (ED) patients.MethodsA retrospective cohort study of patients aged 65 and over who visited the ED of one
Maythita Ittisanyakorn, Sukkhum Ruchichanantakul, Alissara Vanichkulbodee, Jiraporn Sri-on   +3 more
semanticscholar   +1 more source

Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic ...
Ahmed Y. Azzam, Muhammed Amir Essibayi, Dhrumil Vaishnav, Mohammed A. Azab, Mahmoud M. Morsy, Osman Elamin, Adam Elswedy, Oday Atallah, Hana J. Abukhadijah, Adam A. Dmytriw, Amanda Baker, Deepak Khatri, Neil Haranhalli, David J. Altschul   +13 more
wiley   +1 more source