Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases
Advanced Science, EarlyView.Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu +9 more
wiley +1 more source
Characteristic gene expression profile of intestinal mucosa early in life promotes bacterial colonization leading to healthy development of the intestinal environment. [PDF]
Sci RepNishinarita Y +12 more
europepmc +1 more source
Advanced Science, EarlyView.This study identifies a unique physical signature of colorectal cancer in younger adults: their tissues are mechanically stiffer than those in older patients with the same cancer. Furthermore, stromal remodeling in early‐onset colorectal cancer promotes epithelial mechanotransduction and proliferation, showing how mechanical alterations in the tissue ...
Nicole C. Huning +18 more
wiley +1 more source
Standardized Flow Cytometry Method for Absolute Counting of Intraepithelial Lymphocytes in the Intestinal Mucosa Using TruCount<sup>TM</sup> Beads. [PDF]
Bio ProtocJoulain C +4 more
europepmc +1 more source
Deficient UDP‐glucuronosyltransferase detoxification enzyme activity in the small intestinal mucosa of patients with coeliac disease [PDF]
, 2005 Marije S. Goerres +3 more
openalex +1 more source
Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges
Advanced Science, EarlyView.This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li +7 more
wiley +1 more source
Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis. [PDF]
BMC GastroenterolGuo Y +6 more
europepmc +1 more source
Studies on Carbohydrases in the intestinal mucosa of the rabbit (I)
, 1951 Masuta Mori
openalex +2 more sources
Advanced Science, EarlyView.In this study, a single‐cell atlas of 117,019 yak gastrointestinal cells across 54 subtypes identified HNF4A and SREBF2 as key transcription factors targeting MYO6 gene. Cross‐species and multi‐omics analyses reveals epithelial cells as key regulators that, through interactions with microbes, particularly Bacillus, facilitate flexible energy supply and
Chun Huang +12 more
wiley +1 more source