Results 111 to 120 of about 190,688 (308)

Stromal tumor of the lesser omentum: a case report

The Pan African Medical Journal, 2014
Gastrointestinal stromal tumors (GISTs) represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein detected by immunohistochemical staining for the CD117 antigen.
Hossam Behammane, Younes Aggouri, Morad Oussaid, Said Ait Laalim, Imane Toughrai, Karim Ibn majdoub, Khalid Mazaz   +6 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The index endoscopic characteristics associated with gastric neoplasms in serial screening of upper gastrointestinal endoscopy

The Saudi Journal of Gastroenterology
Background: Although biennial upper gastrointestinal endoscopy is recommended for gastric cancer screening in Korea, data regarding the endoscopic characteristics associated with the diagnosis of gastric neoplasms in serial endoscopic screening are ...
Jung Huh, Su Hwan Kim, Kwang Woo Kim, Yun Jin Jeong, Dong Jun Oh, Dong Kee Jang, Heejoon Jang, Ji Bong Jeong, Ji Won Kim, Kook Lae Lee, Hyoun Woo Kang   +10 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Telescoping Intestine in an Adult

Case Reports in Medicine, 2013
Protrusion of a bowel segment into another (intussusception) produces severe abdominal pain and culminates in intestinal obstruction. In adults, intestinal obstruction due to intussusception is relatively rare phenomenon, as it accounts for minority of ...
Khaldoon Shaheen, Naseem Eisa, Abdul Hamid Alraiyes, M. Chadi Alraies, Srinivas Merugu   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dietary Patterns and Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue [PDF]

, 2018
Importance—Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of host immune response to tumor. Evidence also suggests that diet influences intestinal F. nucleatum. However, the role of F.
Bullman, Susan, Cao, Yin, Chan, Andrew T., Drew, David A., Fuchs, Charles S., Fung, Teresa T., Garrett, Wendy S., Giovannucci, Edward L., Hamada, Tsuyoshi, Huttenhower, Curtis, Kostic, Aleksandar D., Kosumi, Keisuke, Masugi, Yohei, Mehta, Raaj S., Meyerhardt, Jeffrey A., Mima, Kosuke, Nishihara, Reiko, Nowak, Jonathan A., Ogino, Shuji, Qian, Zhi Rong, Song, Mingyang, Willett, Walter C., Wu, Kana, Zhang, Xuehong   +23 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Retrospective analysis of the Zebrafish International Resource Center diagnostic data links Pseudocapillaria tomentosa to intestinal neoplasms in zebrafish Danio rerio (Hamilton 1822). [PDF]

J Fish Dis, 2020
Schaaf RM, Sharpton TJ, Murray KN, Kent AD, Kent ML.   +4 more
europepmc   +1 more source