Results 31 to 40 of about 136,851 (292)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Study on Clinical Profile & Management of Acute Intestinal Obstruction [PDF]

Walawalkar International Medical Journal, 2017
Acute intestinal obstruction is a failure of aboral progression of intestinal contents. The overall mortality and morbidity of bowel obstruction is substantial.
Abhijeet Patil, Dhirendra Wagh
doaj  

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Oclusão intestinal por compressas cirúrgicas intraluminais: experiência de cinco casos

Revista do Colégio Brasileiro de Cirurgiões
Despite being unusual, retained foreign bodies after surgical procedures is a matter of great concern for surgeons. The main purpose of this article is to describe five cases of intestinal obstruction due to intraluminal surgical sponges.
Christiano Marlo Paggi Claus, Cesar Giovani Conte, Júlio Cezar Uili Coelho, Renato Valmassoni Pinho   +3 more
doaj   +1 more source

Intestinal pseudo-obstruction with life-threatening hypokalaemia in a patient with adult-onset Still’s disease

European Journal of Case Reports in Internal Medicine, 2023
Adult-onset Still’s disease (AOSD) is a rare autoinflammatory disorder that can lead to a cytokine storm, causing a range of symptoms. Acute intestinal pseudo-obstruction is another rare condition that results in intestinal obstruction without anatomical
Pierre Rossignon, Alain Soupart
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Surgical treatment of colorectal cancer complicated with acute intestinal obstruction

Тазовая хирургия и онкология, 2016
Background. The main reason for urgent complications of colon cancer is an acute intestinal obstruction (AIO). This is complex pathological condition in 90 % of cases caused by colorectal cancer (CRC).Objective – to evaluate radicality of the performed ...
S. N. Schaeva
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Management with Conservative Gastrointestinal Decompression and Intravenous Immunoglobulin Relieved Intestinal Obstruction in Kawasaki Disease: A Case Report

Journal of Clinical Question
Background: Kawasaki disease (KD) is an acute febrile vasculitis that predominantly affects children under 5 years of age. Although gastrointestinal symptoms are common, severe complications, such as intestinal obstruction, are rare but clinically ...
Yuta Baba, Yumeng Zhang, Yuri Ishida, Akira Iwanaga, Aiko Kumamoto, Takeshi Yamanouchi, Shinji Nishimura   +6 more
doaj   +1 more source