Results 31 to 40 of about 130,150 (211)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Analysis of influencing factors and construct a prediction model for postoperative intestinal obstruction of colorectal cancer

结直肠肛门外科
[Objectives] To analyze the influencing factors for postoperative intestinal obstruction of colorectal cancer and construct a prediction model. [Methods] A retrospective analysis was conducted on 300 patients with colorectal cancer admitted to our ...
Wang Zhen, Chen Linyun, Wang Lin, He Hongqin, Mou Kaidong, Liu Feng   +5 more
doaj   +1 more source

A Case Report on the Spontaneous Intraperitoneal Rupture of Urinary Bladder Presenting as Acute Intestinal Obstruction – Lessons Learnt

Lietuvos Chirurgija, 2022
Acute intestinal obstruction is a common surgical emergency. Most of the time, the cause lies in the gastrointestinal track. A 19 year old boy presented with clinical features of acute intestinal obstruction and radiological features suggestive of large
Vipin Venugopal Nair, Pawan Sharma, Swarup Prabhu, Simarjit Singh Rehsi   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Risk factors of intestinal obstruction in pregnancy [PDF]

Саратовский научно-медицинский журнал, 2012
<p>Objective: to study risk factors and options for clinical course of acute intestinal obstruction in pregnancy. Materials and methods. A detailed study of history, clinical course, diagnosis and treatment characteristics of acute intestinal ...
Khvorostukhina N.F., Salov I.A., Rogozhina I.E., Stolyarova U.V.   +3 more
doaj  

Laparoscopic Treatment of Intestinal Obstruction [PDF]

Journal of Acute Care Surgery, 2016
Purpose: Open adhesiolysis has been the favored approach regarding surgical management of intestinal obstruction. Following the development of laparoscopic devices and necessary surgical techniques, laparoscopic treatment of intestinal obstruction and ...
Jae Hun Hur, Byeonghun Oh, Eunyoung Kim, Eun Jung Ahn, Sei-Hyeog Park, Jong-Min Park   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Etiological Spectrum of Dynamic Intestinal Obstruction

Gomal Journal of Medical Sciences, 2004
Background: Intestinal obstruction is a common and potentially dangerous surgical emergency with high morbidity and mortality if managed inappropriately. It is essential to distinguish between its various types. The aim of this study was to determine the
Tariq Wahab Khanzada, Abdul Samad, Champa Sushel   +2 more
doaj  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source