Results 201 to 210 of about 128,811 (259)

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

Surrogate Markers of Intestinal Permeability, Bacterial Translocation and Gut-Vascular Barrier Damage Across Stages of Cirrhosis. [PDF]

Liver Int
Haedge F, Reuken PA, Reißing J, Große K, Frissen M, El-Hassani M, Aschenbach R, Teichgräber U, Stallmach A, Bruns T.   +9 more
europepmc   +1 more source

Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial. [PDF]

Avicenna J Phytomed
Derakhshan AR, Mirsadraee M, Asnaashari A, Salari R, Khadem-Rezaiyan M, Saeidinejat S, Jalali S, Jalali S, Gaffari S.   +8 more
europepmc   +1 more source

Ubiquitination of TFEB increased intestinal permeability to aggravate metabolic dysfunction-associated steatohepatitis. [PDF]

Hepatology
Liu D, Chen L, Wang Z, Li Z, Liu L, Peng L.   +5 more
europepmc   +1 more source

Increased intestinal permeability and bile acid accumulation via inhibition of the FXR-SHP pathway contribute to coumarin-induced systemic inflammation. [PDF]

Microbiol Spectr
Shou N, Wu D, Wang Q, Huang P, Lin Q, Hou S, Fu K, Xu W, Zhang J, Shi Z.   +9 more
europepmc   +1 more source

Targeting the Microbiota Reverses C-Section-Induced Effects on Intestinal Permeability, Microbiota Composition, and Amygdala Gene Expression in the Mouse. [PDF]

Neurogastroenterol Motil
Silva APV, Moloney GM, Sequeira AM, Liber M, Bastiaanssen T, Rea K, Fitzgerald P, Golubeva A, Rodriguez-Aburto M, Renes IB, Knol J, Dinan T, Cryan JF.   +12 more
europepmc   +1 more source

Evaluation of the Pharmacokinetic Interactions of <i>Maytenus ilicifolia</i> Mart. ex Reiss Extracts on Drug Intestinal Permeability and Hepatic Metabolism. [PDF]

ACS Omega
do Nascimento SB, Dos Santos PHG, Costa GHO, Perovani ÍS, Moraes de Oliveira AR, Gonçalves JE, de Castro WV, César IDC.   +7 more
europepmc   +1 more source

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Prediction of intestinal permeability

Advanced Drug Delivery Reviews, 2002
This review focuses on computational methods for the prediction of passive intestinal permeability. Existing computational models are surveyed and assessed in terms of descriptors, model type/complexity, speed of computation, predictive performance, and interpretability.
William J, Egan, Georgio, Lauri
exaly   +3 more sources