Results 201 to 210 of about 127,475 (345)

Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage

, 2014
Sagen Zac-Verghese, Stefan Trapp, Paul Richards, Sophie R. Sayers, Gao Sun, Stephen R. Bloom, Frank Reimann, Fiona M. Gribble, Guy A. Rutter   +8 more
openalex   +1 more source

Soft Robotics and Advanced Technologies for Minimally Invasive Bioprinting: The Future of Internal Organ Repair

Advanced Science, Volume 13, Issue 22, 17 April 2026.
This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu, Nhu An Phan, Sy Trung Ngo, Minh Tri Phan, Thanh‐An Truong, Chi Cong Nguyen, Phuoc Thien Phan, Hoang‐Phuong Phan, Thanh Nho Do, Mai Thanh Thai   +9 more
wiley   +1 more source

Erratum to Safety of cold snare resection techniques for removal of small colon polyps in patients taking clopidogrel and aspirin: a Korean Association for the Study of Intestinal Diseases prospective multicenter study. Gastrointestinal Endoscopy. Volume 101, Issue 4, April 2025, Pages 866-876

Tae‐Geun Gweon, Hyun Gun Kim, Yunho Jung, Seong Ran Jeon, Soo‐Young Na, Yoo Jin Lee, Tae Ho Kim   +6 more
openalex   +2 more sources

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers

Cancer Innovation, Volume 5, Issue 2, April 2026.
Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun, Md Sohel, Zitu Barman, Umme Salma, Lubatul Arbia, Md. Rifat Sarker, Jasmin Akter Jame, Badhan Rani Dey, Sultana Parvin, Md. Shah Poran Shuvo, Md. Shahidul Islam, Tania Mannan, Snygdha Rani Das, Md. Mahmudul Hasan   +13 more
wiley   +1 more source

Colonic Malakoplakia With an Adenomatous Appearance on Magnification Endoscopy: A Case Report. [PDF]

DEN Open
ABSTRACT Malakoplakia is a rare chronic granulomatous disease associated with impaired macrophage phagocytosis of bacteria. Because colonic malakoplakia presents with varied endoscopic appearances, its characteristic features have not been clearly defined, and differentiation from colorectal neoplasms during endoscopy may be difficult. We report a case
Sono S, Kaji K, Miura M, Takayama H, Yasuda K, Arai K, Harada K, Terasaki S.   +7 more
europepmc   +2 more sources

Figure S3 from Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden

, 2023
David C. Montrose, Xi Kathy Zhou, Erin M. McNally, Erika Sue, Rhonda K. Yantiss, Steven S. Gross, Nitai D. Leve, Edward D. Karoly, Chen S. Suen, Lilan Ling, Robert Benezra, Eric G. Pamer, Andrew J. Dannenberg   +12 more
openalex   +1 more source

A Disproportionality Analysis of Immune Checkpoint Inhibitors in Combination With Platinum‐Based Agents Using the FDA Adverse Event Reporting System Database

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Objective Immune checkpoint inhibitors (ICIs) combined with platinum‐based compounds are commonly used in the treatment of certain malignant tumors. This study aims to analyze adverse events (AEs) associated with the combination therapy of ICIs and platinum‐based compounds by using the FAERS database.
Boyi Liu, Wenchao Zhang, Ruizhe Huang, Dinwen Liu, Jiaxing Liu, Ao Han, Yike Li, Danna Chen   +7 more
wiley   +1 more source

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

, 1995
Masanobu Oshima, Hiroko Oshima, Kazuo Kitagawa, Masahiko Kobayashi, C. Itakura, Makoto M. Taketo   +5 more
openalex   +1 more source

Long‐Term Health and Economic Impacts of COVID‐19 Disruptions on Bowel Cancer Inequalities in Victoria, Australia: A Modelling Study

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Introduction The COVID‐19 pandemic significantly disrupted colorectal cancer (CRC) diagnosis and treatment globally. Most research on long‐term impacts has focused on population‐level outcomes, overlooking disparities in under‐screened groups.
Anita Lal, Eliza Mudford, Bedasa Taye Merga, Lan Gao, Craig Sinclair, Kate Broun, Justin M. Yeung, Nikki McCaffrey   +7 more
wiley   +1 more source