Results 221 to 230 of about 7,342,453 (271)

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

A Specimen-Separated Machine Learning Benchmark Toward Real-Time Tissue-Type Identification in Guided Surgery Using Ex Vivo Bovine Laser-Induced Breakdown Spectroscopy. [PDF]

Sensors (Basel)
Sosa-Santos RF, Arce-Diego JL, Fanjul-Vélez F.   +2 more
europepmc   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Evaluation of Postbiotics from <i>Lactiplantibacillus plantarum</i> and <i>Bacillus mojavensis</i> Fermented in Aguamiel on Their Cytotoxic Effect in Breast Cancer Cells, Their In Vivo Effects, and Processing by Spray Drying. [PDF]

Nutrients
García-Ceja A, Zuluaga-López KT, Ortiz-Basurto RI, Tapia-Maruri D, Meza-Jiménez ML, Cardoso-Ugarte GA, Jiménez-Fernández M, Nava P, Pérez-Armendáriz B.   +8 more
europepmc   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Occurrence and Morphometric Characterization of <i>Cysticercus tenuicollis</i> in Sheep From Minas Gerais, Brazil. [PDF]

Vet Med Int
Pereira CAJ, Brito VM, Gomes AL, Becattini RM, Mendes GLV, Rocha ST, Oliveira WG, Silva GHR, de Oliveira SABM, Lima WDS.   +9 more
europepmc   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

The <i>C. elegans</i> WASH complex supports epithelial polarity by promoting endosomal sorting of E-Cadherin. [PDF]

Mol Biol Cell
Irizarry-Barreto P, Smolyn J, Brown V, Ramamurthy B, Soto MC.   +4 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Gut Microbiome of Aquatic Organisms: Role in Immunity Formation and Effects on Aquaculture Productivity. [PDF]

Microorganisms
Khmelevtsova LE, Prazdnova EV, Mazanko MS, Brislavsky YA, Rudoy DV.   +4 more
europepmc   +1 more source