Results 91 to 100 of about 793,315 (309)

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

An Origami-Inspired Endoscopic Capsule with Tactile Perception for Early Tissue Anomaly Detection [PDF]

IEEE Robotics and Automation Letters ( Volume: 9, Issue: 11, November 2024)
Video Capsule Endoscopy (VCE) is currently one of the most effective methods for detecting intestinal diseases. However, it is challenging to detect early-stage small nodules with this method because they lack obvious color or shape features. In this letter, we present a new origami capsule endoscope to detect early small intestinal nodules using ...
arxiv   +1 more source

Effects of Clostridium perfringens iota toxin in the small intestine of mice [PDF]

, 2017
Iota toxin is a binary toxin solely produced by Clostridium perfringens type E strains, and is structurally related to CDT from C. difficile and CST from C. spiroforme.
Bruzzone, Octavio Augusto, Cangelosi, Adriana, Dailoff, Gabriela Cecilia, Díaz Carrasco, Juan María, Fernandez Miyakawa, Mariano Enrique, Geoghegan, Patricia, Leiva, Carlos Leónidas, Redondo, Enzo Alejandro, Redondo, Leandro Martin   +8 more
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Development of Small and Large Intestine

Bezmiâlem Science, 2017
Epithelial components of the organs of the digestive system are derived from endoderm whereas connective tissue and muscle components are derived from mesoderm. At the 3-4th of development, as a result of cephalocaudal and lateral foldings of the embryo,
Mukaddes EŞREFOĞLU, Aslı ÇETİN
doaj   +1 more source

Viscosity's impact on nutrient uptake along the gut [PDF]

Phys. Rev. Fluids 10, 033103 (2025)
Through switching contraction patterns driving digestive flows, the small intestine balances nutrient uptake and waste removal. Complex segmentation contraction patterns are associated with higher nutrient uptake, while peristaltic contractions primarily serve to flush out unused remnants.
arxiv   +1 more source

Intestinal Microecology in Pediatric Surgery-Related Gastrointestinal Diseases Current Insights and Future Perspectives [PDF]

arXiv, 2023
Intestinal microecology is established from birth and is constantly changing until homeostasis is reached. Intestinal microecology is involved in the immune inflammatory response of the intestine and regulates the intestinal barrier function. The imbalance of intestinal microecology is closely related to the occurrence and development of digestive ...
arxiv  

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

КОМПЛЕКСНАЯ КЛИНИКО-ФУНКЦИОНАЛЬНАЯ ОЦЕНКА ТОНКОЙ КИШКИ ПРИ МЕТАБОЛИЧЕСКОМ СИНДРОМЕ

Архивъ внутренней медицины, 2015
Aim: complex investigation of the small intestine functional condition in metabolic syndrome.Materials and methods.120 patients with metabolic syndrome were examined. We used clinical data and complex examination of the small intestine function.
Я. М. Вахрушев, М. В. Ляпина   +1 more
doaj   +1 more source

Digestion Modelling in the Small Intestine : Impact of Dietary Fibre [PDF]

arXiv, 2012
In this work, we continue the modelling of the digestion in the small intestine, started in a previous article, by investigating the effects of dietary fibre. We recall that this model aims at taking into account the three main phenomena of the digestion, namely the transit of the bolus, the degradation of feedstuffs and the absorption through the ...
arxiv