Results 41 to 50 of about 18,065,536 (276)

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Psychological, social and biological determinants of ill health (pSoBid): Study Protocol of a population-based study [PDF]

, 2008
Background: Disadvantaged communities suffer higher levels of physical and mental ill health than more advantaged communities. The purpose of the present study was to examine the psychosocial, behavioural and biological determinants of ill health within ...
Batty, G.D., Deans, K., Sattar, N, Chris J Packard, Batty G David, Burns, H., Millar, Keith, McGinty, A, Millar, K., Ford Ian, Ian Ford, Yoga Nathan (12346540), Tannahill, Carol, Carol Tannahill, Agnes McGinty, Velupillai, YN, McGinty, A., Bezlyak, V., Millar, K, Ian Ford (30666), Burns Harry, Vladimir Bezlyak (587208), Millar Keith, Cavanagh Jonathan, Naveed Sattar, Cavanagh, Jonathan, Tannahill Carol, Paul Shiels, Paul G. Shiels (12592783), Ford, Ian, Jonathan Cavanagh (125077), Bezlyak Vladimir, McGinty Agnes, Chris J. Packard (12592780), Tannahill, C., Keith Millar, Agnes McGinty (212297), Ford, I, Sattar, N., G David Batty, Kevin A. Deans (12592774), Jonathan Cavanagh, Keith Millar (212300), Carol Tannahill (212305), Packard Chris J, Burns, Harry, Ford, I., Bezlyak, Vladimir, Sattar Naveed, Bezlyak, V, Deans, Kevin A., Shiels Paul, Shiels, P, Naveed Sattar (8785), Batty, David G., Harry Burns (125075), David G. Batty (12592771), Burns, H, Packard, C.J., Cavanagh, J, McGinty, Agnes, Velupillai, Y.N., Deans Kevin, Nathan, Yoga, Tannahill, C, Cavanagh, J., Shiels, P., Yoga N Velupillai, Sattar, Naveed, Velupillai Yoga N, Packard, CJ, Harry Burns, Kevin Deans, Batty, GD, Vladimir Bezlyak, Deans, K, Packard, Chris J., Shiels, Paul G.   +77 more
core   +2 more sources

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Serum amyloid A in children and adolescents: association with overweight and carotid intima-media thickness

Einstein (São Paulo), 2023
Objective To compare serum amyloid A concentrations between overweight and eutrophic children and adolescents and to relate it to lipid profiles, glucose tolerance, and carotid intima-media thickness. Methods One hundred children and adolescents (mean
Maria Vitória Mareschi Barbosa, João Carlos Pina Faria, Stephanie Ramos Coelho, Fernando Luiz Affonso Fonseca, Andrea Paula Kafejian Haddad, Fabíola Isabel Suano de Souza, Roseli Oselka Saccardo Sarni   +6 more
doaj   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Associations of prerenal fat, carotid intima–media thickness, and plaque formation in cardiovascular health—a cross-sectional analysis

The Egyptian Journal of Radiology and Nuclear Medicine
Background Prerenal fat, a visceral fat pad with distinct secretory and neural features, has been suggested to be associated with atherosclerosis and serves as a potential independent marker for cardiovascular risk.
Fahimeh Zeinalkhani, Hossein Salehzadeh, Peyman Kamali Hakim, Hadise Zeinalkhani, Mohammad Ghaffari   +4 more
doaj   +1 more source

The relationship between Intima-Media Thickness and Carotid Plaque Characteristics with Incidence and Severity of Premature Coronary Artery Disease

Novelty in Biomedicine, 2023
Background: Carotid intima media thickness (CIMT) and carotid plaque can predict premature coronary heart disease (PCAD) in patients hospitalized due to coronary artery disease or undergoing therapeutic interventions.
Mohammad Haji Aghajani, Masoomeh Raoufi, Roxana Sadeghi, Faezeh Arefinia, Mohammad Parsa Mahjoob   +4 more
doaj  

A Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment

Advanced Science, EarlyView.
The mechanobiological basis of atherosclerotic progression and its contribution to spatial and temporal heterogeneity remain incompletely understood. Spatially resolved AFM measurements revealed that plaque formation and distinct regions (cap fibrosis, intimal fibrosis, and lipid‐rich core) exhibit heterogeneous elastic modulus and viscoelastic ...
Yidan Zhou, Zhuo Chang, Xianjun Wu, Sijie Wang, Yuzhi Zhang, Hao Zhang, Haoyu Xu, Ruining Peng, Zhe Wang, Huiyun Xu, Yu Liu, Guangkui Xu, Nu Zhang, Hui Yang   +13 more
wiley   +1 more source

Relationship between Dietary Intake and Body Composition with Carotid Intima-Media Thickness in Patients with Transient Ischemic Attack

مجله دانشکده پزشکی اصفهان, 2017
Background: Population-based studies in many countries have shown that carotid intima-media thickness (IMT) has a positive relationship with stroke. Some studies have suggested that many of the foods or body composition have effect on the risk of stroke.
Asefeh Kiani, Fariborz Khorvash, Akbar Hasanzadeh, Gholamreza Askari   +3 more
doaj