Results 151 to 160 of about 1,449,476 (289)

A Damage‐Gated Small‐Molecule Chimera Selectively Enhances Mitophagy by Coupling Dysfunctional Mitochondria to Autophagy

Advanced Science, EarlyView.
MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov, Ekaterina А. Guseva, Alexander Yu. Rudenko, Konstantin G. Lyamzaev, Sofya Y. Sokolskaya, Julia A. Golubeva, Maria V. Belopolskaya, Nadezda V. Andrianova, Olga V. Fadeeva, Elena О. Morgun, Elena A. Tukhovskaya, Marina S. Kazakova, Vladimir M. Pavlov, Daria K. Yagoda, Elena I. Marusich, Rose‐Lys Zaranaina, Valeriya B. Vays, Irina M. Vangeli, Egor Y. Plotnikov, Maxim L. Lovat, Lora E. Bakeeva, Arkady N. Murashev, Vladimir I. Polshakov, Olga A. Dontsova, Peter V. Sergiev   +24 more
wiley   +1 more source

CDC\u2019s National Intimate Partner and Sexual Violence Survey

NISVS is an ongoing, nationally representative telephone survey that collects detailed information on IPV, SV, and stalking victimization of adult women and men ages 18 and older in the United States.

core  

FADS2‐STING Signaling in Sertoli Cells Orchestrates Collagen Deposition and Germ Cell Necroptosis in Idiopathic Non‐Obstructive Azoospermia

Advanced Science, EarlyView.
In Sertoli cells of iNOA testes, downregulation of FADS2 activates STING, promoting collagen deposition and peritubular fibrosis while increasing germ‐cell susceptibility to necroptosis. Supplementation with FADS2‐derived PUFAs (GLA and DHA) inhibits STING, alleviates collagen accumulation, and facilitates the recovery of spermatogenesis.
Jiajing Lin, Hongfei Ke, Xiaomin Li, Man Wu, Zhengyan Wu, Zhiying Huang, Feixue Han, Dejian Pang, Shuyan Chen, Tianwen Peng, Yu Lan, Xin Fu, Yingying Zhang, Hyeon Jeong Lee, Zhicong Chen, Geng An   +15 more
wiley   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

Advanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang, Sai Shi, Jianghui Wu, Jingge Zhang, Shuqin Li, Yuyan Hu, Haifeng Yin, Chenguang Zhao, Dong Ma, Xiaohui Xian, Lizhe Liu, Ling Zhao, Xiyun Liu, Zhikai Yu, Lihua Dong, Wenbin Li, Lingyan Zhang, Min Zhang   +17 more
wiley   +1 more source

Hierarchical Organization of Biomaterials in the Formation of Photonic Nanostructures

Advanced Science, EarlyView.
Natural organisms create vibrant structural colors through precisely organized nanostructures formed under mild biological conditions. This review explores how cellulose, chitin, corneous beta‐protein, and melanin form complex nanostructures across molecular, mesoscale, and tissue levels.
Sangyeop Kim, Jihun Kang, Seunghwan Moon, Liliana D'Alba, Matthew D. Shawkey, Jong‐Souk Yeo   +5 more
wiley   +1 more source

A Decision-Making Framework for Selecting Intimate Partner Violence Measures in Health Research. [PDF]

J Nurs Scholarsh
Williams JR, Burton CW, Grant GG, Hatcher A, Villegas N, Sheffield-Abdullah K.   +5 more
europepmc   +1 more source

EZpred: Improving Deep Learning‐Based Enzyme Function Prediction Using Unlabeled Sequence Homologs

Advanced Science, EarlyView.
Schematic of the EZpred pipeline, which provides high‐confidence predictions of enzyme function using a combination of sequence alignments, structural alignments, and deep learning. EZpred can be used to provide substantial increases in the richness of protein function annotations at genomic scales.
Chengxin Zhang, Quancheng Liu, Lydia Freddolino   +2 more
wiley   +1 more source

Intimate Partner Violence Around the Time of Pregnancy and Infant Safe Sleep Practices. [PDF]

J Interpers Violence
Jones BW, Peterson SK, Swedo E, Parks SE, Lambert AE, D'Angelo DV.   +5 more
europepmc   +1 more source

Targeting a Calcium‐Associated Mitochondrial Vulnerability in TET2‐Deficient Myeloid Cells

Advanced Science, EarlyView.
Reduced TET2 function creates a calcium‐associated mitochondrial vulnerability in macrophages that is preferentially exploited by Lanatoside C. The resulting stress promotes apoptosis of TET2‐deficient macrophages, reduces inflammatory and fibrotic injury in human cardiac organoids, and highlights a genotype‐associated myeloid liability that may be ...
Yue Wang, Minh Duc Pham, Despina Stefanoska, Ting Yuan, Arka Provo Das, Chaonan Zhu, Meiqian Wu, Thanh Thuy Duong, Jaskiran Kaur, Yu Hao, Johannes Krefting, Marius Schwab, Jonathan Ward, Maria Duda, Wesley Abplanalp, Moritz von Scheidt, Andreas M. Zeiher, Stefanie Dimmeler, Jaya Krishnan   +18 more
wiley   +1 more source

The Rural Ecological Framework of Intimate Partner Violence (RE-IPV): Social-Ecological Factors and Constrained Agency Among Rural Women. [PDF]

Nurs Inq
Kimber F, Abusbaitan H, Munala L, Luebke J, Walton A, Eyedat A, Gondwe KW, Bement K, Jerome M, Clark C, Mkandawire-Valhmu L.   +10 more
europepmc   +1 more source