Results 181 to 190 of about 111,505 (342)

Beyond Docking: A Multi‐Tier Computational Pipeline for USP7 Inhibitor Optimization

open access: yesChemMedChem, Accepted Article.
Ubiquitin‐specific protease 7 (USP7) is a key deubiquitinating enzyme involved in tumor suppression, DNA repair, and epigenetic regulation. Given its critical role in cancer progression, USP7 has emerged as an attractive therapeutic target. In this study, we employed a multi‐tier computational approach, integrating ligand‐based virtual screening ...
Serdar Durdagi   +3 more
wiley   +1 more source

Gut microbiota composition in the sympatric and diet‐sharing Drosophila simulans and Dicranocephalus wallichii bowringi shaped largely by community assembly processes rather than regional species pool

open access: yesiMeta, Volume 1, Issue 4, December 2022., 2022
The diversity, composition, and network of gut microbiota differed between the sympatric and diet‐sharing Drosophila simulans and Dicranocephalus wallichii bowringi. Host species shape the bacterial and fungal community in two insect hosts by altering the relative contribution of community assembly processes.
Yu‐Xi Zhu   +8 more
wiley   +1 more source

A Comprehensive CYP2D6 Drug–Drug–Gene Interaction Network for Application in Precision Dosing and Drug Development

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Conducting clinical studies on drug–drug‐gene interactions (DDGIs) and extrapolating the findings into clinical dose recommendations is challenging due to the high complexity of these interactions. Here, physiologically‐based pharmacokinetic (PBPK) modeling networks present a new avenue for exploring such complex scenarios, potentially informing ...
Simeon Rüdesheim   +14 more
wiley   +1 more source

Indicators of Intimate Partner Violence in Women's Employment

open access: bronze, 2000
J McFarlane   +5 more
openalex   +1 more source

Loss of SMARCB1 evokes targetable epigenetic vulnerabilities in epithelioid sarcoma

open access: yes
Cancer Communications, EarlyView.
Jia Xiang Jin   +12 more
wiley   +1 more source

Seaweed Aquaculture for Carbon Farming: An Assessment Under the EU's QU.A.L.ITY (Quantification, Additionality, Long‐Term Storage, Sustainability) Framework

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT There is growing interest in establishing a seaweed farming industry in Europe, and this industry has the potential for being a mechanism for atmospheric carbon dioxide removal (CDR). The EU recognises the potential of CDR to help meet climate change targets, but also acknowledges the importance of creating credible markets for CDR ecosystem ...
Adam D. Hughes   +3 more
wiley   +1 more source

Into the crossfire: evaluating the use of a language model to crowdsource gun violence reports [PDF]

open access: yesarXiv
Gun violence is a pressing and growing human rights issue that affects nearly every dimension of the social fabric, from healthcare and education to psychology and the economy. Reliable data on firearm events is paramount to developing more effective public policy and emergency responses. However, the lack of comprehensive databases and the risks of in-
arxiv  

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