Results 41 to 50 of about 1,449,476 (289)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Healthcare providers’ experience of identifying and caring for women subjected to sex trafficking: a qualitative study

BMC Women's Health
Background Men’s violence against women, including human trafficking for sexual exploitation, is a severe threat to global health. Healthcare providers are uniquely positioned to identify and care for women subjected to human trafficking for sexual ...
Mikaela Andersson, Karin Örmon
doaj   +1 more source

Previous experience of family violence and intimate partner violence in pregnancy

Revista de Saúde Pública, 2017
OBJECTIVE To estimate differential associations between the exposure to violence in the family of origin and victimization and perpetration of intimate partner violence in pregnancy.
Ana Bernarda Ludermir, Thália Velho Barreto de Araújo, Sandra Alves Valongueiro, Maria Luísa Corrêa Muniz, Elisabete Pereira Silva   +4 more
doaj   +1 more source

Current intimate partner violence and associated factors among sero-positive women attending Adama town ART Clinics, Central Ethiopia 2019

International Journal for Equity in Health, 2022
Background Intimate partner violence against women is a behavior within an intimate relationship that causes physical, sexual, or psychological harm to the victim. It is well recognized as a gross violation of human rights and affects the health of women,
Girma Garedew Goyomsa, Teklu Arga Albe, Sisay Abebe Debela, Leul Deribe Kitaw   +3 more
doaj   +1 more source

Witness of Intimate Partner Violence in Childhood and Perpetration of Intimate Partner Violence in Adulthood [PDF]

Epidemiology, 2010
At least half a million women are victims of intimate partner violence in the United States annually, resulting in substantial harm. However, the etiology of violence to intimate partners is not well understood. Witnessing such violence in childhood has been proposed as a principal cause of adulthood perpetration, yet it remains unknown whether the ...
Andrea L, Roberts, Stephen E, Gilman, Garrett, Fitzmaurice, Michele R, Decker, Karestan C, Koenen   +4 more
openaire   +2 more sources

Global and regional estimates of violence against women [PDF]

, 2013
The report presents a global systematic review of scientific data on the prevalence of two forms of violence against women: violence by an intimate partner (intimate partner violence) and sexual violence by someone other than a partner (non-partner ...
Claudia Garcia-Moreno, Christina Pallitto   +1 more
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Intimate partner violence during pregnancy and risk of still birth in hospitals of Tigray region Ethiopia

Italian Journal of Pediatrics, 2020
Background Pregnancy may represent a time of exceptional vulnerability to intimate partner violence because of changes in women’s conditions. Despite the fact that intimate partner violence during pregnancy confers considerable risk to the health of the ...
Kahsay Zenebe Gebreslasie, Solomon Weldemariam, Gelawdiyos Gebre, Mihret-Ab Mehari   +3 more
doaj   +1 more source

Same-sex intimate partner homicide in Australia [PDF]

, 2014
This study uses data from the National Homicide Monitoring Program within a context of national and international research to describe what is known about the trends and key characteristics of same-sex intimate partner homicide in Australia.
Alexandra Gannoni, Tracy Cussen
core