Results 51 to 60 of about 158,041 (284)

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Programmable Pentamolecular Cross‐Scale Imaging Reveals the Multiplicative Synergistic Effect of High‐Fat / High‐Salt Diet on Atherosclerosis

Advanced Science, EarlyView.
This study demonstrates multifactorial lifestyle impacts on the pathogenesis and progression of cardiovascular diseases by a nanofluorescence sensor array for detecting four redox species and protein phosphorylation levels. Through cross‐scale fluorescence imaging of rats with different diets, we revealed that compared with single dietary interventions,
Jin Li, Na Zhao, Mengmeng Lu, Ruize Zhao, Wei Zhang, Ping Li, Yue Tang, Wen Zhang, Hui Wang, Bo Tang   +9 more
wiley   +1 more source

La violence énonciative dans le récit de vie d’Alice Cherki, Mémoire anachronique Lettre à moi-même et à quelques autres

Akofena
Résumé : Notre objectif est d’étudier la violence énonciative dans le récit de vie d’Alice Cherki (2016), Nous tenterons de montrer les stratégies linguistiques par lesquelles se manifeste la violence dans ce livre de mémoire.
Souad BRAHMI
doaj   +1 more source

The effects of a shopping mall on housing prices: a case study in Hangzhou

International Journal of Strategic Property Management, 2018
There are few studies on the externalities of shopping malls affecting the housing market. This study aims to discuss two issues: (1) What is the intensity of the impact of a shopping mall? (2) When does the external influence of a shopping mall begin to
Ling Zhang, Jiantao Zhou, Eddie C. M. Hui, Haizhen Wen   +3 more
doaj   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

L’implicite dans Sexe et mensonges de  Leila SLIMANI : de l’intime à l’extime [PDF]

Akofena
Résumé : L’intime est le secret de l’âme qui cherche à être extériorisé ou à devenir extime. Dans son ouvrage Sexe et mensonges la vie sexuelle au Maroc, l’auteure raconte les confidences de ses personnages rebelles pleines de souffrances et de blessures
Fatima EL KINANI
doaj   +1 more source

Boethius and the Block Universe: Physical and Metaphysical Considerations of Time [PDF]

, 2012
In this exploration of the nature of time, the author shows that more than a superficial belief in a creator God invites the person of faith to engage with some of the unsettling questions presented by modern physics and cosmology. He considers how human
Kerr, S.O.Sc., John Maxwell
core   +1 more source

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

Advanced Science, EarlyView.
An effector subset of TRM, defined as CD49a+PD1hi CD8+ TRM, represents a BHLHE40‐orchestrated resident immune component that, rather than circulating cells, plays as a major contributor to allograft rejection. ABSTRACT Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation ...
Junbo Li, Bo Yang, Tianhui Pan, Xi Zhou, Zhibo Ma, Du Tang, Bowen Xie, Jing Liu, Zhishui Chen, Peixiang Lan   +9 more
wiley   +1 more source

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

Advanced Science, EarlyView.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen   +8 more
wiley   +1 more source

Visco-resistive shear wave dissipation in magnetic X-points [PDF]

, 2006
We consider the viscous and resistive dissipation of perpendicularly polarized shear waves propagating within a planar magnetic X-point. To highlight the role played by the two-dimensional geometry, the damping of travelling Alfvèn waves that propagate ...
Craig, Ian J.D., Fruit, G.
core   +4 more sources