Results 21 to 30 of about 105,922 (209)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
ToxicsIllicit drug use is common among attendees of electronic dance music (EDM) festivals, but is often significantly underreported by participants. The current study aimed to compare the prevalence and over- and under-reporting of illicit drug use among ...
Kristin Feltmann +6 more
doaj +1 more source
The case series of baclofen intoxication
Journal of Education, Health and Sport, 2019 Baclofen, a gamma-amino butyric acid type B (GABAb) inhibitor, is commonly used in management of spasticity and other medical conditions, such as alcohol dependency.
Michał Kos +4 more
doaj +1 more source
Amantadine toxic effect and acute psychosis – a case report
Journal of Education, Health and Sport, 2023 Introduction and purpose: The pandemic of COVID-19 has induced patients to use different ways to struggle with SARS-CoV-2 infection. Amantadine has become more popular as a supportive drug in the treatment of COVID-19 symptoms.
Dariusz Gruca +3 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Pediatria i Medycyna Rodzinna, 2019 Aim: The aim of the study was to retrospectively assess cases of intentional dextromethorphan intoxication which were the reason for admissions to the Department of Paediatrics and Gastroenterology at the Medical University of Lublin between 2008 and ...
Karol Krawiec +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Medycyna Pracy, 2018 Methemoglobin is an oxidized form of hemoglobin that is not capable of carrying oxygen. Exposure to exogenous oxidizing agents can cause severe methemoglobinemia and subsequent hypoxia.
Jacek Piechocki +2 more
doaj +1 more source
Poisoning with e-cigarette liquid (VPG Power Smoke Baze) - case report
Journal of Education, Health and Sport, 2023 Introduction and purpose: E-cigarettes have emerged as an alternative to traditional tobacco smoking. Toxicological studies have investigated the composition and potential toxicity of e-cigarette liquid components.
Marlena Zając +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source