Results 51 to 60 of about 238,875 (301)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

MESCAL INTOXICATION. [PDF]

The Lancet, 1897
n ...
openaire   +1 more source

Pregnenolone Can Protect the Brain from Cannabis Intoxication

Science, 2014
Counteracting Cannabis What is the role of steroid hormones in vulnerability to addiction? Working with rodents, Vallée et al. (p. 94) found that all major drugs of abuse (morphine, cocaine, alcohol, nicotine) increase neurosteroid levels, with the ...
M. Vallée, S. Vitiello, L. Bellocchio, Etienne Hébert-Chatelain, S. Monlezun, E. Martín-García, F. Kasanetz, G. Baillie, F. Panin, A. Cathala, V. Roullot-Lacarrière, Sandy Fabre, Dow P. Hurst, D. Lynch, Derek M. Shore, V. Deroche-Gamonet, U. Spampinato, J. Revest, Rafael Maldonado, P. Reggio, R. Ross, G. Marsicano, Pier Vincenzo Piazza   +22 more
semanticscholar   +1 more source

Single‐Atom Pt Anchoring on Self‐Doped ZrO2@G‐C3N4 Nanostructure Enables Efficient Photocatalytic Seawater Hydrogen Evolution

Advanced Science, EarlyView.
Grain‐like Zr3+‐ZrO2 and Pt single atoms are integrated into an S‐scheme Zr3+‐ZrO2@g‐C3N4 heterostructure to enable efficient visible‐light‐driven seawater hydrogen production. The combined effect of Pt single‐atom sites and the S‐scheme charge‐transfer pathway accelerates carrier separation, preserves strong redox ability, and markedly enhances ...
Hezheng Sun, Yifan Guo, Xin Yu, Yajie Tian, Feng Gao, Bin Wang, Yanting Tang, Dani S. Assi, Vellaisamy A. L. Roy   +8 more
wiley   +1 more source

Emergencies in AUD: acute alcohol intoxication and alcohol withdrawal syndrome [PDF]

Excessive alcohol consumption is linked to several consequences involving health, social, working, relational and economic fields. Acute alcohol Intoxication is the direct consequence of high alcohol consumption, particularly if consumed in a short time ...
Antonio Mirijello, Maria Maddalena D’Errico, Gabriella Pacilli, Angelo D’Agruma, Salvatore De Cosmo, Cristina d’Angelo, Pamela Piscitelli   +6 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Effect of Acetaldehyde Intoxication and Withdrawal on NPY Expression: Focus on Endocannabinoidergic System Involvement

Frontiers in Psychiatry, 2014
Acetaldehyde (ACD), the first alcohol metabolite, plays a pivotal role in the rewarding, motivational, and addictive properties of the parental compound.
F. Plescia, A. Brancato, R. Marino, Carlotta Vita, M. Navarra, C. Cannizzaro   +5 more
semanticscholar   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Acute ethanol gavage attenuates hemorrhage/resuscitation-induced hepatic oxidative stress in rats [PDF]

, 2012
Acute ethanol intoxication increases the production of reactive oxygen species (ROS). Hemorrhagic shock with subsequent resuscitation (H/R) also induces ROS resulting in cellular and hepatic damage in vivo.
Henrich, Dirk, Marzi, Ingo, Lehnert, Mark, Wilhelm, Kerstin, Wang, Minhong, Relja, Borna   +5 more
core   +1 more source

Treatment of lithium intoxication: facing the need for evidence

International Journal of Bipolar Disorders, 2015
Lithium has been used as the gold standard in the treatment of major depressive and bipolar disorders for decades. Due to its narrow therapeutic index, lithium toxicity is a common clinical problem.
Robert E. Haussmann, Michael Bauer, S. Bonin, P. Grof, Ute Lewitzka   +4 more
semanticscholar   +1 more source