Advanced Science, EarlyView.Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider +20 more
wiley +1 more source
A systematic review on intra-abdominal pressure in severely burned patients [PDF]
, 2014 Objective Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are complications that may occur in severely burned patients. Evidenced based medicine for these patients is in its early development.
Breederveld, R.S. (Roelf S.) +3 more
core +1 more source
Integration of inspiratory and expiratory intra-abdominal pressure: a novel concept looking at mean intra-abdominal pressure [PDF]
Annals of Intensive Care, 2012 The intra-abdominal pressure (IAP) is an important clinical parameter that can significantly change during respiration. Currently, IAP is recorded at end-expiration (IAPee), while continuous IAP changes during respiration (ΔIAP) are ignored. Herein, a novel concept of considering continuous IAP changes during respiration is presented.Based on the ...
Ahmadi-Noorbakhsh, Siavash +1 more
openaire +3 more sources
Advanced Science, EarlyView.Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang +12 more
wiley +1 more source
Is intra-abdominal hypertension a missing factor that drives multiple organ dysfunction syndrome? [PDF]
, 2014 In a recent issue of Critical Care, Cheng and colleagues conducted a rabbit model study that demonstrated that intra-abdominal hypertension (IAH) may damage both gut anatomy and function. With only 6 hours of IAH at 25 mmHg, these authors observed an 80%
De Waele, Jan +3 more
core +2 more sources
Advanced Science, EarlyView.This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu +8 more
wiley +1 more source
Intra-Abdominal Pressure Monitoring By Nurses For Early Detection Of Abdominal Compartment Syndrome And Early Decompressed Laparotomy In Comparison With Need To Laparotomy By Physical Exam. [PDF]
, 2016 :Background& Objective:Abdominal compartment syndrome is as potentially lethal condition caused by any event that produces intra-abdominal hypertension. The most common cause is blunt abdominal trauma.
Ali Sheikhi, R., Heidari, M.
core
Peritoneal adhesions after laparoscopic gastrointestinal surgery [PDF]
, 2014 Although laparoscopy has the potential to reduce peritoneal trauma and post-operative peritoneal adhesion formation, only one randomized controlled trial and a few comparative retrospective clinical studies have addressed this issue.
MAIS, VALERIO
core +1 more source
Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare
Advanced Science, EarlyView.Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu +10 more
wiley +1 more source
Comparison of intra-abdominal pressure measurement and physical exam for diagnosis of surgery indication in patients with abdominal compartment syndrome due to blunt trauma [PDF]
, 2011 Background & Aims: Increase in abdominal pressure can lead to the so-called intra-abdominal compartment syndrome (ACS) that is often observed during the first 24 hours after sever abdominal trauma and surgery.
Heydari, M., Shahbazi, S., Shekhei, R.A.
core