Results 41 to 50 of about 1,686,049 (292)

Analgesics effect of intra-articular bupivacaine injection on pain score in anterior cruciate ligament surgery: a randomized clinical trial

, 2020
<p>Abstract Background: The aim of this study was to examine the effects of injection timing and drainage clamps on patient pain scores in intra-articular local anesthetic applications after arthroscopic anterior cruciate ligament (ACL ...
serdar menekşe
core   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

Intra-articular injection choice for osteoarthritis: making sense of cell source—an updated systematic review and dual network meta-analysis

Arthritis Research & Therapy, 2022
Background Intra-articular injection is indicated for mild or moderate osteoarthritis (OA). However, the superiority of cell-based injection and the role of diverse cell sources are still unclear.
Yijian Zhang, Huilin Yang, Fan He, Xuesong Zhu   +3 more
doaj   +1 more source

Intra-articular Nodular Fasciitis: An Unexpected Diagnosis for a Joint Lesion: A Case Report [PDF]

, 2014
Pathological lesions in and around a joint can arise from underlying dermis, subcutis, deep muscle, bone or synovium. Clinical presentation can include joint pain, joint swelling, palpable masses and mechanical restriction.
S Selvarajan, SS Leon Foo, KO Ong, MF Michelle Chan   +3 more
core   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Is Hyaluronic Acid Intra-Articular Injection Better Than Corticosteroid Intra Articular Injection At Reducing Pain In Patients With Knee Osteoarthritis? [PDF]

, 2019
OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Hyaluronic Acid intra articular injection is better than Corticosteroid intra articular injection at reducing pain in patients with knee osteoarthritis.” STUDY DESIGN ...
Cohen, Madison
core   +1 more source

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis [PDF]

, 2014
Introduction\ud Recent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the severity of experimental ...
Huard, Johnny, Kobayashi, M, Cummins, James H, Takayama, Koji, Kobayashi, Makoto, Matsushita, T, Kawakami, Yohei, Greco, N, Kuroda, Ryosuke, Kuroda, R, Kurosaka, Masahiro, Fu, Freddie H, Kawakami, Y, Cummins, JH, Takayama, K, Huard, J, Greco, Nick, Matsushita, Takehiko, Fu, FH, Kurosaka, M, Johnny Huard, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda, James H Cummins, Yohei Kawakami, Koji Takayama, Nick Greco, Freddie H Fu, Makoto Kobayashi   +29 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Comparison of efficacy of intra-articular morphine and steroid in patients with knee osteoarthritis

Journal of Anaesthesiology Clinical Pharmacology, 2012
Introduction: Primary therapeutic aim in treatment of osteoarthritis of the knee is to relieve the pain of osteoarthritis. The aim of this study was to compare the efficacy of intra-articular triamcinolone with intra-articular morphine in pain relief due
Serbülent Gökhan Beyaz
doaj   +1 more source