Results 71 to 80 of about 872,133 (249)

Intra-articular drug injections in the combination treatment of rheumatic diseases [PDF]

, 2015
In clinical practice, intra-articular injections of glucocorticoids (GC) are widely used to treat chronic joint inflammatory diseases, osteoarthritis (OA), and extra-articular soft tissue involve-ment.
Yu. A. Olyunin
core   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Efficiency of intraarticular injection of PRP and hyaluronic acid combination in osteoarthritis knee: A systematic review and meta-analysis

Journal of Orthopaedic Reports
Background: Intra-articular injection is a viable option in treatment of osteoarthritis knee, especially for patients who do not tolerate pharmacological oral therapy, when drugs are no longer effective, or for those who want to delay or avoid surgical ...
G. Gopinath
doaj   +1 more source

Evaluation of Needle Positioning During Blind Intra-Articular Hip Injections for Osteoarthritis: Fluoroscopy Versus Arthrography

, 2009
Diracoglu D, Alptekin K, Dikici F, Balci Hi, Ozcakar L, Aksoy C. Evaluation of needle positioning during blind intra-articular hip injections for osteoarthritis: fluoroscopy versus arthrography.
Aksoy, Cihan, alptekin, Kerem, Diracoglu, Demirhan, OZCAKAR, Levent, Dikici, Fatih, Balci, Halil İbrahim, Halil İbrahim Balcı, Kerem Alptekin, Fatih Dikici, Demirhan Dıraçoğlu, Levent Özçakar, Cihan Aksoy   +11 more
core   +1 more source

Spatially Confined/Ligand‐Directed Ultrabright NIR‐AIE Nanoprobe for In Vitro Rapid Detection and In Situ Imaging of Bacterial Septic Arthritis

Advanced Science, EarlyView.
Inorganic PbS quantum dots spatially confine AIEgens and enable cooperative luminescence within a ligand‐directed core–shell–shell nanoassembly, generating ultrabright NIR PPANPs with enhanced fluorescence and photothermal performance. The platform enables 10‐min S.
Yujian Li, Jia Shu, Sijia Lv, Leilei Qin, Xuefeng Luo, PengCheng Xiao, Huan Cai, Xin Gao, Yan Zhao, Haotian Zhou, Yaji Yang, Zhenglin Zhu, Shijia Ding, Juan Li, Rui Chen, Wei Huang   +15 more
wiley   +1 more source

A randomized, phase IIa study to assess the systemic exposure of triamcinolone acetonide following injection of extended-release triamcinolone acetonide or traditional triamcinolone acetonide into both knees of patients with bilateral knee osteoarthritis

Therapeutic Advances in Musculoskeletal Disease, 2019
Background: Intra-articular corticosteroids are commonly used for pain relief in patients with knee osteoarthritis. Simultaneous intra-articular corticosteroid (CS) knee injections may be beneficial for the ~80–90% of patients who present with, or ...
Alan Kivitz, Louis Kwong, Tammi Shlotzhauer, Joelle Lufkin, Amy Cinar, Scott Kelley   +5 more
doaj   +1 more source

Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis

BMC Musculoskeletal Disorders, 2021
Background Intra-articular (IA) corticosteroid (CS) injections are the mainstay of treatment for symptomatic management in knee osteoarthritis (OA), particularly in the UK.
Michael McLarnon, Neil Heron
doaj   +1 more source

Intra-articular Nodular Fasciitis: An Unexpected Diagnosis for a Joint Lesion: A Case Report [PDF]

, 2014
Pathological lesions in and around a joint can arise from underlying dermis, subcutis, deep muscle, bone or synovium. Clinical presentation can include joint pain, joint swelling, palpable masses and mechanical restriction.
S Selvarajan, SS Leon Foo, KO Ong, MF Michelle Chan   +3 more
core   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source