Cellular Oncology, 2004 Objectives: As part a Program Project to evaluate emerging optical technologies for cervical neoplasia, our group is performing quantitative histopathological analysis of biopsies from 1800 patients. Several methodological issues have arisen with respect
Martial Guillaud +9 more
doaj +1 more source
Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies
BMC Cancer, 2005 Background The development of non-small cell lung carcinoma proceeds through a series of well-defined pathological steps before the appearance of invasive lung carcinoma.
Lam Stephen +5 more
doaj +1 more source
Basal-like breast cancers: from pathology to biology and back again [PDF]
, 2018 Human breast cancers referred to as "basal-like" are of interest because they lack effective therapies and their biology is poorly understood. The term basal-like derives from studies demonstrating tumor gene expression profiles that include some ...
Eaves, Connie J., Gusterson, Barry
core +1 more source
Actinic keratoses show variable histological basal growth patterns - a proposed classification adjustment [PDF]
, 2017 Background: Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now, the importance of basal epidermal growth patterns of AK has not been studied. Objective: To
Dirschka, T. +6 more
core +1 more source
Human Vaccines & Immunotherapeutics, 2023 Cervical cancer is the fourth most common cancer in women, with a high disease burden worldwide. Human papillomavirus (HPV) vaccination reduces HPV-related infection and associated cervical lesions and cancers.
Siwei Deng +15 more
doaj +1 more source
Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. [PDF]
, 2012 Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of PDGs with mucinous metaplasia and
Butler, Peter C +5 more
core +1 more source
Frontiers in Medicine, 2018 Objectives: To evaluate the efficacy and safety of gonadotropin-releasing hormone (GnRH) agonist after endometrial resection in women suffering early stage endometrial carcinoma (EC) and/or endometrial intra-epithelial neoplasia (EIN).Design: A ...
Stéphanie Tock +5 more
doaj +1 more source
Evaluation of HPV infection and smoking status impacts on cell proliferation in epithelial layers of cervical neoplasia. [PDF]
PLoS ONE, 2014 Accurate cervical intra-epithelial neoplasia (CIN) lesion grading is needed for effective patient management. We applied computer-assisted scanning and analytic approaches to immuno-stained CIN lesion sections to more accurately delineate disease states ...
Martial Guillaud +8 more
doaj +1 more source
Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice [PDF]
, 2016 INTRODUCTION Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53.
Blackburn, Anneke C +4 more
core +1 more source
Dynamics of the intratumoral immune response during progression of high-grade serous ovarian cancer [PDF]
, 2018 PURPOSE: Tumor-infiltrating lymphocytes (TILs) have an established impact on the prognosis of high-grade serous ovarian carcinoma (HGSOC), however, their role in recurrent ovarian cancer is largely unknown.
Braicu, I +18 more
core +4 more sources