Results 51 to 60 of about 5,765,551 (303)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Genetic relationship underlying the intra-individual variation in nutrition studies

, 1998
The role of intra-individual variation studies was highlighted by Prof. P.V. Sukhatme both theoretically as well as by analysis of actual live data on intake and expenditure collected over time in a number of individuals. The genetic significance of this
Narain, P.
core   +1 more source

Robust intra-individual estimation of structural connectivity by Principal Component Analysis

NeuroImage, 2021
Fiber tractography based on diffusion-weighted MRI provides a non-invasive characterization of the structural connectivity of the human brain at the macroscopic level.
Lidia Konopleva, Kamil A. Il’yasov, Shi Jia Teo, Volker A. Coenen, Christoph P. Kaller, Marco Reisert   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Absence of Excess Intra-Individual Variability in Retinal Function in People With Schizophrenia

Frontiers in Psychiatry, 2020
People with schizophrenia exhibit increased intra-individual variability in both behavioral and neural signatures of cognition. Examination of intra-individual variability may uncover a unique functionally relevant aspect of impairment that is not ...
Samantha I. Fradkin, Samantha I. Fradkin, Samantha I. Fradkin, Molly A. Erickson, Docia L. Demmin, Docia L. Demmin, Steven M. Silverstein, Steven M. Silverstein, Steven M. Silverstein   +8 more
doaj   +1 more source

Intra-Individual and Intraspecific Terpenoid Diversity in Erodium cicutarium

Plants, 2021
The chemodiversity between and within individuals of several plant species is remarkable and shaped by the local habitat environment and the genetic background. The forb Erodium cicutarium (Geraniaceae) is globally distributed and partly invasive.
Elisabeth Johanna Eilers
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Intra- and inter-individual variance of gene expression in clinical studies. [PDF]

PLoS ONE, 2012
BACKGROUND: Variance in microarray studies has been widely discussed as a critical topic on the identification of differentially expressed genes; however, few studies have addressed the influence of estimating variance. METHODOLOGY/PRINCIPAL FINDINGS: To
Wei-Chung Cheng, Wun-Yi Shu, Chia-Yang Li, Min-Lung Tsai, Cheng-Wei Chang, Chaang-Ray Chen, Hung-Tsu Cheng, Tzu-Hao Wang, Ian C Hsu   +8 more
doaj   +1 more source

Assessment of the inter and intra-individual variability in the jump of agility dogs [PDF]

Authorship contribution statement: Patricia López: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing ...
Miró, Francisco, López, Patricia, Gutiérrez Cepeda, Luna   +2 more
core   +1 more source