Results 141 to 150 of about 6,454,413 (294)

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Intra-individual reaction time variability and all-cause mortality over 17 years: A community-based cohort study

, 2015
Background: very few studies have examined the association between intra-individual reaction time variability and subsequent mortality. Furthermore, the ability of simple measures of variability to predict mortality has not been compared with more ...
Bunce, David, Mackinnon, Andrew, Batterham, Philip, Christensen, Helen   +3 more
core   +1 more source

Bridging Biosensing and Hardware‐Level Data Security With a Conjugated Radical Polymer

Advanced Materials, EarlyView.
A conjugated radical polymer provides two complementary functions within a common material platform: sensitive dopamine biosensing and device‐specific stochastic electrical responses for security. The work demonstrates a materials‐based approach for combining bioelectronic signal acquisition with hardware‐level authentication while maintaining the ...
Hoyeon Lee, Jaehyoung Ko, Dinh Cung Tien Nguyen, Yeong Kwon Kim, Daeun Kim, Soo Jin Cho, Sung Gap Im, Byung Chul Jang, Byung Joon Moon, Yongho Joo   +9 more
wiley   +1 more source

Charge Storage and Dark Photocatalysis in Multivariate Ti‐Based Metal‐Organic Frameworks

Advanced Materials, EarlyView.
The mixed‐linker series of the titanium‐based metal–organic framework COK‐47 enables systematic tuning of photoresponsiveness and (dark) photocatalytic activity, deepening our understanding of structure‐property‐function relationships. Tailored metal‐to‐ligand charge transfer between the secondary building units (metal‐oxo layers and organic linkers ...
Julia E. Knapp, Bibhuti Bhusan Rath, Borja Ortín‐Rubio, Lukas Bauder, Kristina Gjorgjevikj, Saunak Das, Mariia Ferree, Frédéric Laquai, Lorenzo Tesi, Bettina Baumgartner, Simon Krause, Bettina V. Lotsch   +11 more
wiley   +1 more source

Wafer‐Scale Direct Growth of Ultraclean Monolayer Amorphous Carbon on c‐Sapphire by Remote Catalytic Dehydrogenation

Advanced Materials, EarlyView.
Remote catalytic dehydrogenation enables the direct growth of monolayer amorphous carbon on a 2‐inch sapphire wafer by thermal CVD. Spatial separation of the catalyst from the growth substrate eliminates metallic residue and post‐growth processing, yielding a wafer‐scale uniform film with a random polygonal sp2‐hybridized carbon network that exhibits ...
Muhammad Sabbtain Abbas, Imhwan Kim, Seokje Lee, Yasir Hassan, Jihwan Kim, Eunsu Lee, Han Ik Kim, Yoonkang Kim, Gyu‐Chul Yi   +8 more
wiley   +1 more source

Cognitive and Neuroimaging Biomarker Intra-Individual Variability in Alzheimer’s Disease

Abstract Background Greater cognitive intra-individual variability (IIV) reflects increased heterogeneous performance across cognitive domains and has been linked to a higher risk of Alzheimer’s disease (AD).
Teo, Min Huey, Taong, Malcolm Ren Qing, Kan, Cheuk Ni, Tan, Chin Hong   +3 more
openaire   +2 more sources

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

Laser‐Induced Local De‐Doping in Organic Semiconductors

Advanced Materials Technologies, EarlyView.
The polymer PBTTT‐C14 doped with the small molecule acceptor F4TCNQ is considered as a benchmark material system. Mask‐free, microscale patterning of the doping level via laser‐induced heating and sublimation of dopant molecules is shown. Controlling laser irradiance and swath spacing allows dopant level control with laser‐limited resolution, opening ...
Christian Rainer, Aleksandr Perevedentsev, Daniel Ryklin, Rasmus R. Schröder, Gerardo Hernandez‐Sosa, Uli Lemmer   +5 more
wiley   +1 more source

Chitin‐Chitosan Cryogels for the Reversible Sequestration and Recovery of Heavy Metals From Wastewater

Advanced Materials Technologies, EarlyView.
Chitin‐chitosan cryogels with degrees of N‐acetylation from 12.2% to 71.4% are fabricated by dissolution, coagulation and lyophilization for the sequestration of heavy metals from water. Colorimetry and differential pulse voltammetry showed controlled adsorption and desorption capacities for As5+, Co2+ and Cu2+, making this material attractive for ...
Marta García‐Castrillo, Maialen Uribarrena, Jorge Sáiz, Guillermo Copello, Erlantz Lizundia   +4 more
wiley   +1 more source