Results 61 to 70 of about 6,454,413 (294)

High-resolution analysis of individual Drosophila melanogaster larvae uncovers individual variability in locomotion and its neurogenetic modulation

Open Biology, 2023
Neuronally orchestrated muscular movement and locomotion are defining faculties of multicellular animals. Due to its simple brain and genetic accessibility, the larva of the fruit fly Drosophila melanogaster allows one to study these processes at ...
Michael Thane, Emmanouil Paisios, Torsten Stöter, Anna-Rosa Krüger, Sebastian Gläß, Anne-Kristin Dahse, Nicole Scholz, Bertram Gerber, Dirk J. Lehmann, Michael Schleyer   +9 more
doaj   +1 more source

Intra- and inter-observer variability for LV parameters.

, 2019
Intra- and inter-observer variability for LV parameters.
Yutaka Otsuji (602947), Tetsuji Kitano (7329623), Yosuke Nabeshima (6269873), Masaaki Takeuchi (4184002), Yasuhiko Abe (7329626)   +4 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Neuronal Intra-Individual Variability Masks Response Selection Differences between ADHD Subtypes—A Need to Change Perspectives

Frontiers in Human Neuroscience, 2017
Due to the high intra-individual variability in attention deficit/hyperactivity disorder (ADHD), there may be considerable bias in knowledge about altered neurophysiological processes underlying executive dysfunctions in patients with different ADHD ...
Annet Bluschke, Witold X. Chmielewski, Moritz Mückschel, Veit Roessner, Christian Beste, Christian Beste   +5 more
doaj   +1 more source

Assessment of patient-to-patient and intra-individual human abdominal skin immune cell variability

Archives of Medical Science, 2022
Introduction The objective of the study was to characterize the baseline intra-individual and inter-individual variability of immune cell subsets within abdominoplasty skin specimens.
Margaret Veitch, Craig Layt, Emma Raymond, Andrew J. Croaker, James W. Wells   +4 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Short-term variability of Alzheimer’s disease plasma biomarkers in a mixed memory clinic cohort

Alzheimer’s Research & Therapy
Background For clinical implementation of Alzheimer’s disease (AD) blood-based biomarkers (BBMs), knowledge of short-term variability, is crucial to ensure safe and correct biomarker interpretation, i.e., to capture changes or treatment effects that lie ...
Frederikke Kragh Clemmensen, Mathias Holsey Gramkow, Anja Hviid Simonsen, Nicholas J. Ashton, Hanna Huber, Kaj Blennow, Henrik Zetterberg, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen   +9 more
doaj   +1 more source

Aerobic fitness and intra-individual variability of neurocognition in preadolescent children [PDF]

Brain and Cognition, 2013
This study examined behavioral and neuroelectric intra-individual variability (IIV) in preadolescent children during a task requiring variable amounts of cognitive control. The current study further examined whether IIV was moderated by aerobic fitness level. Participants performed a modified flanker task, comprised of congruent and incongruent arrays,
Robert Davis, Moore, Chien-Ting, Wu, Matthew B, Pontifex, Kevin C, O'Leary, Mark R, Scudder, Lauren B, Raine, Christopher R, Johnson, Charles H, Hillman   +7 more
openaire   +2 more sources

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)

Scientific Reports, 2017
Processing speed is an updated diagnostic factor for neurocognitive disorders (NCD) in DSM-5. This study investigated the characteristics of processing speed and their diagnostic values in NCD patients.
Hanna Lu, Sandra S. M. Chan, Linda C. W. Lam   +2 more
doaj   +1 more source