Results 201 to 210 of about 801,934 (258)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Assessment of corneal endothelial morphology in retinal vein occlusion. [PDF]

BMC Ophthalmol
Erdağ M, Aktaş K, Canleblebici M, Dal A, Yıldırım H, Balbaba M.   +5 more
europepmc   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

Longitudinal, Intra-Individual Stability of Untargeted Plasma and Cerebrospinal Fluid Metabolites. [PDF]

Metabolites
Rocha B, Jonaitis EM, Hamwi A, Engelman CD.   +3 more
europepmc   +1 more source

Time‐Resolved SAXS Reveals Distinct Millisecond Metal‐Induced Conformational Dynamics of Monomeric α‐Synuclein

Advanced Science, EarlyView.
Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann, Miriam Dos Santos Pinto, Xue Wang, Jinghui Luo   +3 more
wiley   +1 more source

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu, Mengqin Yuan, Yini Shang, Jiahao Chen, Fei Hou, Lihong Wang, Wei Jiang   +6 more
wiley   +1 more source

Temporal and intra-horse consistency of circulating myostatin concentrations in Thoroughbred racehorses. [PDF]

Sci Rep
Hanousek K, O'Hara V, Riddell DO, Piercy RJ.   +3 more
europepmc   +1 more source

Multi-institutional MRI-based radiomic pilot study to measure the variations between scanner vendors and imaging sessions. [PDF]

Front Oncol
Duong S, Lee D, Glide-Hurst C, Paliwal B, Crosby J, Boss M, Cui Y, Huang M, Li H, Sheikh K, Kim T, Monroe J, Oh JH, Xiao Y, Sohn JW.   +14 more
europepmc   +1 more source

Topological and Functional Diversity of Gut Microbiota Metabolism Across the Human Lifespan. [PDF]

Metabolites
Pérez-Rocher B, Reyes-Prieto M, Ruiz-Ruiz S, Palmer-Rodríguez P, Castro JA, Moya A, Llabrés-Segura M.   +6 more
europepmc   +1 more source