Results 171 to 180 of about 1,675,350 (299)

CNN4Essential: a convolutional neural network model for predicting bacterial gene essentiality based on multi-feature fusion. [PDF]

BMC Genomics
Ye YN, Zhou RY, Li LY, Yuan HT, Xia J, Li YW, Zeng Z, Zhang XY.   +7 more
europepmc   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Development and Internal Validation of a Web-Based Dynamic Nomogram for Dynamic Risk Stratification of Early Bacterial Infection in Liver Transplant Recipients. [PDF]

Ann Transplant
Ngo TD, Nguyen TT, Le KN, Nguyen AHN, Do TT, Huynh HX, Le KV, Do NV.   +7 more
europepmc   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Un calendario del dodicesimo XII secolo nella Biblioteca Capitolare di Intra Cod. 16 [PDF]

, 1985
Mariani, C., Biblioteca Capitolare (Intra), Pisoni, Pier Giacomo, Frigerio, Pierangelo   +3 more
core  

PFGPred: a stack ensemble classifier for the identification of fusion genes in plants. [PDF]

DNA Res
Hamid F, Mukherjee K, Chaudhary S, Kaushik L, Kumar S.   +4 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

ProtDML: label-aware representation learning for broad-spectrum protein function prediction. [PDF]

Brief Bioinform
Kan Y, Yi G.
europepmc   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Early risk prediction model for intra-abdominal hypertension in adult ICU patients: a prospective cohort study. [PDF]

Front Med (Lausanne)
Tan Y, Kou Y, Du J, Chen Y, Ma Y, Yu H, Li S, Pan C.   +7 more
europepmc   +1 more source