Results 211 to 220 of about 2,273,192 (285)

Accurate prediction of activity cliff compounds based on bioactivity profiles depends on assay nearest neighbor relationships. [PDF]

J Cheminform
Abe R, Miyao T, Bajorath J.
europepmc   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

A dual-fMRI investigation of interpersonal emotion regulation: Predicting strategy selection and implementation success from effective brain connectivity. [PDF]

Imaging Neurosci (Camb)
Ngombe N, Czekóová K, Gajdoš M, Kessler K, Brázdil M, Shamay-Tsoory S, Shaw DJ.   +6 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Protein stereo-folding and proteostasis: A new path for clinical and translational medicine. [PDF]

Clin Transl Med
Wang Y, Qiu Y, Wang X.
europepmc   +1 more source

BOMIFA: biologically informed multi-omics integration with graph contrastive learning for cancer prognosis in women. [PDF]

Brief Bioinform
Lu Z, Wang J, Liang Y, Lin Z, Tan Y, Ma Q, Zhou W, Zhao Y, Xu S.   +8 more
europepmc   +1 more source

Machine Learning for Predicting Critical Postoperative Interventions: Proof-of-Concept Study Using the INSPIRE Dataset. [PDF]

JMIR Perioper Med
Shukla M, Fodor P, Yelika S, Ahn N.
europepmc   +1 more source

Construction and validation of a risk prediction model for early ventilator-induced diaphragm dysfunction in mechanically ventilated patients. [PDF]

Front Med (Lausanne)
Long MQ, Liu YT.
europepmc   +1 more source

Multimodal contrastive learning for integrating molecular representations and cellular phenotypes in drug-target interaction prediction. [PDF]

Bioinformatics
Lai YJ, Liang T, Chen PY, Tsai YC, Tseng GC, Huang Y, Chiu YC.   +6 more
europepmc   +1 more source

DSA-NRP: No-Reflow Prediction From Angiographic Perfusion Dynamics in Stroke EVT. [PDF]

IEEE Trans Med Imaging
Athreya S, Olivares C, Ismail A, Nael K, Speier W, Arnold CW.   +5 more
europepmc   +1 more source