Results 71 to 80 of about 1,009,280 (268)

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

open access: yesAdvanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie   +12 more
wiley   +1 more source

Effect of Intra-Row Spacing on Haricot Bean (Phaseolus vulgaris L.) Production in humid Tropics of Southern Ethiopia. [PDF]

open access: yes, 2015
Field experiment was conducted at the research farm of Dilla University in 2015 main cropping season, with the objective of determining the optimum plant spacing for better productivity of haricot bean under the humid conditions of Dilla, southern ...
Alemayehu, Yacob
core   +1 more source

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

open access: yesAdvanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su   +5 more
wiley   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang   +5 more
wiley   +1 more source

Effect of row spacing and speeding rate on Alfalfa (Hassawi) seed yield and two related traits

open access: yes, 1992
A field experiment was conducted at King Faisal University Research and Experimental Station, Al-Hassa during 1984 to 1987 to study the effect of row spacing and seeding rate on the seed yield of Hassawi alfalfa. The experiment included six row spacings:
Koriem, Younes Saadawi   +1 more
core  

Effects of Intra and Inter-Row Spacing on Yield and Yield Components of Mung Bean (Vigna radiate L.) [PDF]

open access: yes, 2018
Maintaining optimum planting space spacing is the most important agronomic practice for determining effective population density to increase growth and yield of Mungbean crop.
Wubetu, Abayneh
core   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi   +7 more
wiley   +1 more source

Maximization of Seed Size Tuber Production in Early Bulking Potato (Solanum tuberosum L.) Variety Kufri Khyati

open access: yesInternational Journal of Bio-Resource and Stress Management, 2017
A field experiment was conducted at ICAR Central Potato Research Station Gwalior, MP, during 2015–16 and 2016–17 to study the effect of intra-row spacing, nitrogen levels and date of haulm killing on production of higher proportion of seed size tubers ...
Murlidhar Sadawarti   +6 more
doaj  

MANUFACTURING AND TESTING OF LOCAL RICE TRANSPLANTING MACHINE [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2022
Mechanical transplanting of rice is considered one of the safest methods of rice cultivation. It is also one of the most desirable methods for Egyptian farmers, saving about 70% of the seeds, saving labor costs, better plant density, water saving, and ...
Tarek FOUDA   +4 more
doaj  

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy