Results 261 to 270 of about 568,973 (334)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

SynOmics: integrating multi-omics data through feature interaction networks. [PDF]

Brief Bioinform
Alif MN, Zhang W.
europepmc   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

Risk prediction models for postoperative intra-abdominal infection in patients with digestive system tumors: a systematic review. [PDF]

Front Oncol
Wang Y, Wang L, Du Y, Li J, Shi Y, Zhang Z, Peng L.   +6 more
europepmc   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

Deep learning-based multimodal pathogenomics integration for precision cancer prognosis. [PDF]

J Transl Med
Feng X, Song G, Zhang Y, Guo L, Jiang Y, Gong W, Feng Y, Xu C, Yang Y, He M.   +9 more
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Diagnostic Accuracy and Stability of Multimodal Large Language Models for Hand Fracture Detection: A Multi-Run Evaluation on Plain Radiographs. [PDF]

Diagnostics (Basel)
Güler I, Grieb G, Kraus A, Lautenbach M, Stelling H.   +4 more
europepmc   +1 more source

Radiomics features combined with clinical and CT features for predicting the Ki-67 index in stage T1 non-small cell lung cancer patients: a multicenter study. [PDF]

J Thorac Dis
Chen D, Xu P, He Z.
europepmc   +1 more source

The pcMPO-AF rule for predicting postoperative atrial fibrillation after coronary artery bypass grafting. [PDF]

Sci Rep
Luo L, Wang T, Peng T, Gao C, Shu Y, Yang H, Zhou W, Liu Y.   +7 more
europepmc   +1 more source