Results 351 to 360 of about 2,992,178 (408)

Validation of an LC-MS/MS Method for the Simultaneous Intracellular Quantification of the CDK4/6 Inhibitor Abemaciclib and the EZH2 Inhibitors GSK126 and Tazemetostat. [PDF]

Pharmaceutics
Senekowitsch S, Freitag T, Dubinski D, Freiman TM, Maletzki C, Hinz B.   +5 more
europepmc   +1 more source

Cell Membrane Vesicle Camouflaged Artificial Cells

Advanced Functional Materials, EarlyView.
Artificial cells camouflaged with a cell membrane vesicle coating are able to assemble into synthetic aggregates that exhibit rudimentary communication capabilities. Additionally, when these artificial cells are equipped with antioxidant capabilities, they are able to protect the intracellular homeostasis in HepG2 cells present in semi‐synthetic ...
Paula De Dios Andres, Stefan Pendlmayr, Noga Gal, Cathrine Abild Meyer, Cecilie Ryberg, Olav Vestrheim, Noel Angelo Kalacas, Fatih Demir, Markus M. Rinschen, Karsten Haupt, Rajeshwar Prosad Mookerjee, Brigitte Städler   +11 more
wiley   +1 more source

The gut microbiota metabolite trimethylamine N-oxide promotes cardiac hypertrophy by activating the autophagic degradation of SERCA2a. [PDF]

Commun Biol
Lei D, Liu Y, Liu Y, Jiang Y, Lei Y, Zhao F, Li W, Ouyang Z, Chen L, Tang S, Ouyang D, Li X, Li Y.   +12 more
europepmc   +1 more source

Engineering Novel DNA Nanoarchitectures for Targeted Drug Delivery and Aptamer Mediated Apoptosis in Cancer Therapeutics

Advanced Functional Materials, EarlyView.
Designer DNA Architecture‐templated Drug Conjugates (DDA‐DCs) are comprised of a DNA nanomaterial decorated with multiple drug‐loaded DNA aptamers. DDA‐DCs use a combination of multiple aptamer types, each recognizing a different membrane protein to achieve precise targeting of cancer cells.
Abhisek Dwivedy, Dhyanesh Baskaran, Gaurav Sharma, Wei Hong, Dhanush Gandavadi, Abhichart Krissanaprasit, Joonsu Han, Yusheng Liu, Zack Zimmers, Tshepo Mafokwane, Ichrak Hayah, Neha Chauhan, Mengxi Zheng, Sherwood Yao, Keith Fraser, John S. Decker, Xiaohe Jin, Hua Wang, Adam D. Friedman, Xing Wang   +19 more
wiley   +1 more source

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

Differential expression of genes associated with lipid import, β-oxidation and lactate oxidation induced by <i>Mycobacterium tuberculosis</i> curli pili in broth culture compared to intracellular bacilli within THP-1 macrophages. [PDF]

J Med Microbiol
Ashokcoomar S, Pillay M.
europepmc   +1 more source

Defective Intracellular Insulin/IGF-1 Signaling Elucidates the Link Between Metabolic Defect and Autoimmunity in Vitiligo. [PDF]

Cells
Caputo S, Papaccio F, Marrapodi R, Lopez G, Iacovelli P, Pacifico A, Migliano E, Cota C, Di Nardo A, Picardo M, Bellei B.   +10 more
europepmc   +1 more source

Molecular Targeting of Intracellular Bacteria by Homotypic Recognizing Nanovesicles for Infected Pneumonia Treatment. [PDF]

Biomater Res
Wang X, Zhou H, Li D, Zhao Z, Peng K, Xu X, Wang JJ, Wang Y, Wang J, Zhang JJ, Wan SS, Shi MQ, Chen J, Ding XG, Ji FH.   +14 more
europepmc   +1 more source

Differential association of EphA2 intracellular regions in biased signaling. [PDF]

J Biol Chem
Zapata-Mercado E, Rainwater RR, Özdemir E, Azarova EV, Krzyscik MA, Pasquale EB, Hristova K.   +6 more
europepmc   +1 more source