Results 131 to 140 of about 198,097 (261)

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Protective Functions of β-Alanyl-L-Histidine and Glycyl-L-Histidyl-L-Lysine Glycoconjugates and Copper in Concert

Antioxidants
Two endogenous peptides, β-alanyl-L-histidine, named carnosine (Car), and glycyl-L-histidyl-L-lysine (GHK), derived from the matricellular protein Secreted Protein Acidic and Rich in Cysteine (SPARC), share many beneficial functions.
Irina Naletova, Enrico Rizzarelli
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Proteins and Peptides from Food Sources with Effect on Satiety and Their Role as Anti-Obesity Agents: A Narrative Review

Background/Objective: Obesity, clinically defined as a body mass index (BMI) of 30 kg/m2 or higher, is a medical condition characterized by the excessive accumulation of body fat, which can lead to adverse health consequences.
Armando J. Martínez, Daniel Guajardo-Flores, Mayvi Alvarado-Olivarez, Elvia Cruz-Huerta, Gloricel Serena-Romero, Anaís Ignot-Gutiérrez   +5 more
core   +1 more source

Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications

Exploration of Targeted Anti-tumor Therapy
Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal ...
Taiga Maemoto, Yuto Sasaki, Fumiya Okuyama, Yuichi Kitai, Kenji Oritani, Tadashi Matsuda   +5 more
doaj   +1 more source

2PT140 Computational design of small peptide inhibotrs of protein-protein interactions in intracellular signaling(The 50th Annual Meeting of the Biophysical Society of Japan)

Seibutsu Butsuri, 2012
Yamagishi, Junya, Okimoto, Noriaki, Kasai, Takuma, Okada, Mariko, Imamoto, Akira, Taiji, Makoto   +5 more
openaire   +2 more sources

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Molecular regulation of calcium‐sensing receptor (CaSR)‐mediated signaling

Chronic Diseases and Translational Medicine
Calcium‐sensing receptor (CaSR), a family C G‐protein‐coupled receptor, plays a crucial role in regulating calcium homeostasis by sensing small concentration changes of extracellular Ca2+, Mg2+, amino acids (e.g., L‐Trp and L‐Phe), small peptides, anions
Li Tian, Corey Andrews, Qiuyun Yan, Jenny J. Yang   +3 more
doaj   +1 more source

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

1P043 Computational design of short peptide inhibitors of protein-protein interactions in intracellular signaling mediated by CRK-SH2(01B. Protein:Structure & Function,Poster)

Seibutsu Butsuri, 2013
Yamagishi, Junya, Okimoto, Noriaki, Kasai, Takuma, Suenaga, Atsushi, Okada, Mariko, Imamoto, Akira, Taiji, Makoto   +6 more
openaire   +2 more sources