Results 61 to 70 of about 504,058 (195)

Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway

BMC Bioinformatics, 2011
Background LRP6 is a membrane protein crucial in the initiation of canonical Wnt/β-catenin signalling. Its function is dependent on its proline-serine rich intracellular domain.
Liu Chengcheng, Yao Mingxi, Hogue Christopher WV   +2 more
doaj   +1 more source

Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis.

PLoS ONE, 2019
Deregulation of proteostasis is a main feature of many age-related diseases, often leading to the accumulation of toxic oligomers and insoluble protein aggregates that accumulate intracellularly or in the extracellular space. To understand the mechanisms
Joao Vasco Ferreira, Ana Rosa Soares, José S Ramalho, Teresa Ribeiro-Rodrigues, Catarina Máximo, Mónica Zuzarte, Henrique Girão, Paulo Pereira   +7 more
doaj   +1 more source

Cellular delivery of antibodies: effective targeted subcellular imaging and new therapeutic tool [PDF]

, 2010
It is already more than a century since the pioneering work of the Nobel Laureate Ehrlich gave birth to the side chain theory1, which helped to define antibodies and their ability to target specific biological sites.
Andrew L. Lewis, Giuseppe Battaglia, Irene Canton, Marzia Massignani, Nicholas J. Warren, Nisa Patikarnmonthon, Steven P. Armes   +6 more
core   +1 more source

A statistical model for in vivo neuronal dynamics [PDF]

, 2014
Single neuron models have a long tradition in computational neuroscience. Detailed biophysical models such as the Hodgkin-Huxley model as well as simplified neuron models such as the class of integrate-and-fire models relate the input current to the ...
Pfister, Jean-Pascal, Surace, Simone Carlo   +1 more
core   +7 more sources

Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress

Redox Biology, 2022
Reactive sulfur species (RSS) play a role in redox homeostasis; however, adaptive cell responses to excessive intracellular RSS are not well understood. Therefore, in this study, we generated transgenic (Tg) mice overexpressing cystathionine gamma-lyase (
Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai   +11 more
doaj   +1 more source

Disentangling astroglial physiology with a realistic cell model in silico [PDF]

, 2018
Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry.
A Araque, A Chvatal, A Grosche, A Panatier, A Verkhratsky, A Volterra, A Wallraff, AM Reeves, B Djukic, BA MacVicar, BS Khakh, C Giaume, C Henneberger, CC Fink, DA Rusakov, DA Rusakov, DA Rusakov, DE Bergles, E Scemes, E Shigetomi, EA Bushong, EA Newman, F Ding, F Oschmann, G Seifert, G Ullah, G Wallach, GG Viola, I Patrushev, J Golowasch, J Grosche, J Schaff, J Sibille, K Hama, K Ogata, K Thurley, K Zheng, K Zheng, KC Chen, KP Lehre, KP Lehre, KY Zheng, LP Savtchenko, LP Savtchenko, M Nedergaard, M Pitta De, M Pitta De, MA Castro Di, MD Haustein, MJ Berridge, ML Hines, ML Hines, MR Witcher, N Bazargani, N Hernjak, N Medvedev, P Kofuji, PX Cao, R Srinivasan, R Ventura, RL Rungta, S Anders, S Sylantyev, T Hofer, T Manninen, TaufiqUrRahman, TW Chen, V Parpura, WN Ross, Z Wang, Z Zhang   +70 more
core   +3 more sources

Space in systems biology of signaling pathways – towards intracellular molecular crowding in silico [PDF]

FEBS Letters, 2005
How cells utilize intracellular spatial features to optimize their signaling characteristics is still not clearly understood. The physical distance between the cell‐surface receptor and the gene expression machinery, fast reactions, and slow protein diffusion coefficients are some of the properties that contribute to their intricacy.
Takahashi, K, Vel Arjunan, SN, Tomita, M, Arjunan, Satya   +3 more
openaire   +3 more sources

Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models

Communications Biology
Most of our knowledge of protein structure and function originates from experiments performed with purified proteins resuspended in dilute, buffered solutions.
Jan Rynes, Eva Istvankova, Michaela Dzurov Krafcikova, Enrico Luchinat, Letizia Barbieri, Lucia Banci, Kristyna Kamarytova, Tomas Loja, Bohumil Fafilek, Gustavo Rico-Llanos, Pavel Krejci, Libor Macurek, Silvie Foldynova-Trantirkova, Lukas Trantirek   +13 more
doaj   +1 more source

A mathematical model for calculating the effect of toroidal geometry on the measured magnetic field [PDF]

, 2009
A mathematical model to calculate the measured magnetic field from a stimulated nerve has been presented in the past. Traditionally, electrodes have been used to measure these propagating action signals in nerves, but a less invasive technique is to use ...
Skoczelas, Brenda M.
core   +1 more source

Magnetic susceptibility anisotropy of myocardium imaged by cardiovascular magnetic resonance reflects the anisotropy of myocardial filament α-helix polypeptide bonds. [PDF]

, 2015
BackgroundA key component of evaluating myocardial tissue function is the assessment of myofiber organization and structure. Studies suggest that striated muscle fibers are magnetically anisotropic, which, if measurable in the heart, may provide a tool ...
Dibb, Russell, Liu, Chunlei, Qi, Yi
core   +1 more source