Results 71 to 80 of about 504,058 (195)
P2X2 receptors supply extracellular choline as a substrate for acetylcholine synthesis
FEBS Open Bio, 2022 Acetylcholine (ACh), an excitatory neurotransmitter, is biosynthesized from choline in cholinergic neurons. Import from the extracellular space to the intracellular environment through the high‐affinity choline transporter is currently regarded to be the
Takuma Maruyama +4 more
doaj +1 more source
The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation. [PDF]
, 2019 Allosteric ligands modulate protein activity by altering the energy landscape of conformational space in ligand-protein complexes. Here we investigate how ligand binding to a K+ channel's voltage sensor allosterically modulates opening of its K ...
Angueyra, Juan M +6 more
core +1 more source
Manipulation of Host Cholesterol by Obligate Intracellular Bacteria
Frontiers in Cellular and Infection Microbiology, 2017 Cholesterol is a multifunctional lipid that plays important metabolic and structural roles in the eukaryotic cell. Despite having diverse lifestyles, the obligate intracellular bacterial pathogens Chlamydia, Coxiella, Anaplasma, Ehrlichia, and Rickettsia
Dhritiman Samanta +4 more
doaj +1 more source
Flux imbalance analysis and the sensitivity of cellular growth to changes in metabolite pools [PDF]
, 2013 Stoichiometric models of metabolism, such as flux balance analysis (FBA), are classically applied to predicting steady state rates - or fluxes - of metabolic reactions in genome-scale metabolic networks. Here we revisit the central assumption of FBA, i.e.
Mehta, Pankaj +2 more
core
npj Parkinson's Diseaseα-synucleinopathies progression involves the spread of α-synuclein aggregates through the extracellular space (ECS). Single-particle tracking studies showed that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity.
J. Estaun-Panzano +9 more
doaj +1 more source
Toxics, 2016 Single cell imaging mass spectrometry opens up a complete new perspective for strategies in toxicological risk assessment and drug discovery. In particular, time-of-flight secondary ion mass spectrometry (ToF-SIMS) with its high spatial and depth ...
Harald Jungnickel +2 more
doaj +1 more source
Frontiers in Computational Neuroscience, 2015 To understand information processing in neuronal circuits, it is important to infer how a sensory stimulus impacts on the synaptic input to a neuron. An increase in neuronal firing during the stimulation results from pure excitation or from a combination
Ryota eKobayashi +3 more
doaj +1 more source
Liquid-liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept. [PDF]
Cell Mol Life Sci, 2022 Antifeeva IA +8 more
europepmc +1 more source
A Monte Carlo model checker for probabilistic LTL with numerical constraints [PDF]
, 2008 We define the syntax and semantics of a new temporal logic called probabilistic LTL with numerical constraints (PLTLc). We introduce an efficient model checker for PLTLc properties.
Donaldson, R, Gilbert, D
core
Generic principles of active transport
, 2006 Nonequilibrium collective motion is ubiquitous in nature and often results in a rich collection of intringuing phenomena, such as the formation of shocks or patterns, subdiffusive kinetics, traffic jams, and nonequilibrium phase transitions.
Franosch, Thomas +4 more
core +2 more sources