Results 11 to 20 of about 833,009 (242)

The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial

Brain : a journal of neurology, 2023
Therapeutics to reduce intracranial pressure are an unmet need. Preclinical data have demonstrated a novel strategy to lower intracranial pressure using glucagon-like peptide-1 (GLP-1) receptor signalling.
J. Mitchell, H. Lyons, Jessica Katie Walker, A. Yiangou, O. Grech, Z. Alimajstorovic, N. Greig, Yazhou Li, G. Tsermoulas, K. Brock, S. Mollan, A. Sinclair   +11 more
semanticscholar   +1 more source

Clinical Presentation, Investigation Findings, and Treatment Outcomes of Spontaneous Intracranial Hypotension Syndrome

JAMA Neurology, 2021
This systematic review and meta-analysis provides an objective summary of the available evidence on the clinical presentation, investigations findings, and treatment outcomes for spontaneous intracranial hypotension.
L. D’Antona, Melida Andrea Jaime Merchan, Anna Vassiliou, L. Watkins, I. Davagnanam, A. Toma, M. Matharu   +6 more
semanticscholar   +1 more source

Case Report: Congenital Intracranial Kaposiform Hemangioendothelioma Treated With Surgical Resection

Frontiers in Surgery, 2022
BackgroundKaposiform hemangioendothelioma (KHE) is a locally aggressive but non-metastatic vascular neoplasm. Most studies have been restricted to small case series of limited generalizability.
Yingjie Cai, Jiayi Li, Wei Yang, Nan Zhang, Hailang Sun, Weiping Zhang, Ming Ge   +6 more
doaj   +1 more source

IL-1β and HMGB1 are anti-neurogenic to endogenous neural stem cells in the sclerotic epileptic human hippocampus

Journal of Neuroinflammation, 2021
Background The dentate gyrus exhibits life-long neurogenesis of granule-cell neurons, supporting hippocampal dependent learning and memory. Both temporal lobe epilepsy patients and animal models frequently have hippocampal-dependent learning and memory ...
Malik Zaben, Niels Haan, Feras Sharouf, Aminul Ahmed, Lars E. Sundstrom, William P. Gray   +5 more
doaj   +1 more source

Effectiveness of Bariatric Surgery vs Community Weight Management Intervention for the Treatment of Idiopathic Intracranial Hypertension

JAMA Neurology, 2021
Key Points Question Is bariatric surgery superior to a community weight management intervention in sustaining the weight loss necessary to achieve sustained remission among patients with idiopathic intracranial hypertension?
S. Mollan, J. Mitchell, R. Ottridge, Magda Aguiar, A. Yiangou, Z. Alimajstorovic, D. Cartwright, O. Grech, G. Lavery, C. Westgate, V. Vijay, W. Scotton, B. Wakerley, T. Matthews, A. Ansons, S. Hickman, J. Benzimra, C. Rick, R. Singhal, A. Tahrani, K. Brock, E. Frew, A. Sinclair   +22 more
semanticscholar   +1 more source

Case report: Primary intracranial EWs/PNET in adults: Clinical experience and literature review

Frontiers in Oncology, 2022
IntroductionAdult primary intracranial Ewing sarcomas (EWs)/primitive neuroectodermal tumors (PNETs) are extremely rare, with only 30 patients published before us.
Xianwen Hu, Qi Huang, Ju Wang, Dandan Li, Pan Wang, Jiong Cai   +5 more
doaj   +1 more source

Association of Systolic Blood Pressure with Progression of Symptomatic Intracranial Atherosclerotic Stenosis [PDF]

Journal of Stroke, 2017
Background and Purpose Elevated blood pressure (BP) is associated with greater severity of intracranial atherosclerotic stenosis (ICAS) and increased risk of ischemic stroke.
Jong-Ho Park, Bruce Ovbiagele, Keun-Sik Hong, Sun U. Kwon   +3 more
doaj   +1 more source

Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial

Clinical Cancer Research, 2021
Purpose: We report the intracranial efficacy of selpercatinib, a highly potent and selective RET inhibitor, approved in the United States for RET fusion-positive non–small cell lung cancers (NSCLC).
V. Subbiah, J. Gainor, G. Oxnard, D. Tan, D. Owen, B. Cho, H. Loong, C. McCoach, J. Weiss, Y. J. Kim, L. Bazhenova, Keunchil Park, H. Daga, B. Besse, O. Gautschi, C. Rolfo, E. Zhu, J. Kherani, Xin Huang, Suhyun Kang, A. Drilon   +20 more
semanticscholar   +1 more source

MRI evidence for altered venous drainage and intracranial compliance in mild traumatic brain injury. [PDF]

, 2013
To compare venous drainage patterns and associated intracranial hydrodynamics between subjects who experienced mild traumatic brain injury (mTBI) and age- and gender-matched controls.
Alperin, Noam, Ertl-Wagner, Birgit, Heinen, Florian, Koerte, Inga, Laubender, Ruediger P., Lee, Sang, Pomschar, Andreas, Straube, Andreas   +7 more
core   +7 more sources

Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial

Journal of Clinical Oncology, 2020
PURPOSE In the HER2CLIMB study, patients with human epidermal growth factor receptor 2 (HER2)–positive breast cancer with brain metastases (BMs) showed statistically significant improvement in progression-free survival (PFS) with tucatinib.
N. Lin, V. Borges, C. Anders, R. Murthy, E. Paplomata, E. Hamilton, S. Hurvitz, S. Loi, A. Okines, V. Abramson, Philippe Bédard, Mafalda Oliveira, V. Mueller, A. Zelnak, M. DiGiovanna, T. Bachelot, A. J. Chien, R. O'Regan, A. Wardley, A. Conlin, D. Cameron, L. Carey, G. Curigliano, K. Gelmon, S. Loibl, J. Mayor, S. McGoldrick, Xuebei An, E. Winer   +28 more
semanticscholar   +1 more source