Results 291 to 300 of about 847,907 (389)

HDL‐C/LDL‐C Ratio and All‐Cause Mortality in Populations at High CVD Risk: A Prospective Observational Cohort Study

open access: yesChronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background The ratio of high‐density lipoprotein cholesterol (HDL‐C) to low‐density lipoprotein cholesterol (LDL‐C) predicts cardiovascular disease (CVD) endpoints, yet its prognostic validity in high‐risk populations and for type 2 diabetes mellitus (T2DM)‐related adverse events remains unestablished. Methods This study included 32,609 people
Biting Lin   +10 more
wiley   +1 more source

Development of Novel Anticancer Pyrazolopyrimidinones Targeting Glioblastoma

open access: yesChemMedChem, EarlyView.
Pyrazolo[1,5‐α]pyrimidinone derivatives exhibit selective cytotoxicity towards glioblastoma (GBM) cells over noncancerous cells. Structure–activity relationship studies identifies a lead compound with significant cytotoxicity activity, inducing apoptosis and necrosis in GBM cells, without affecting noncancerous cells. This demonstrates the potential of
Kate Byrne   +5 more
wiley   +1 more source

Identifying the need for surgical intervention in pediatric bacterial meningitis: single-center experience. [PDF]

open access: yesFront Pediatr
Boyraz M   +6 more
europepmc   +1 more source

Variation in Neurodegeneration‐Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Possible pleiotropic effects of apolipoprotein E4 (APOE E4) in individuals with congenital brain malformations are relatively unknown. Our goal was to determine if neurodegeneration‐linked brain region volumes differ significantly between E4 carriers and noncarriers in young adults with spina bifida (SB). Methods Eleven individuals ( 
Joan M. Jasien   +8 more
wiley   +1 more source

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