Results 1 to 10 of about 46,795 (162)

Romiplostim use in pregnant women with immune thrombocytopenia

American Journal of Hematology, Volume 98, Issue 1, Page 31-40, January 2023., 2023
Abstract Treatment for immune thrombocytopenia (ITP) in pregnancy is hampered by the lack of fetal safety evidence of maternally‐administered medications. The Pregnancy Surveillance Program (PSP) collected patient information from 2017–2020 for pregnancy, birth outcomes, and adverse events (AEs) for 186 women exposed to romiplostim from 20 days before ...
James B. Bussel, Nichola Cooper, Tatiana Lawrence, Marc Michel, Emilie Vander Haar, Kejia Wang, Hongmei Wang, Hossam Saad   +7 more
wiley   +1 more source

Poor expression of miR‐195‐5p can assist the diagnosis of cerebral vasospasm after subarachnoid hemorrhage and predict adverse outcomes

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Objective Patients with spontaneous subarachnoid hemorrhage (SAH) may develop refractory arterial cerebral vasospasm (CVS), which is the leading cause of death in SAH patients. This study explored the clinical diagnostic value of serum miR‐195‐5p levels in CVS after SAH (SAH + CVS) and its relationship with the prognosis of SAH + CVS.
Yong Li, Senyuan Yang, Xiaobin Zhou, Runlong Lai   +3 more
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3‐WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet, Riikka Immonen, Ofer Prager, Alon Friedman, Jens P. Bankstahl, David K. Wright, Terence J. O'Brien, Heidrun Potschka, Olli Gröhn, Neil G. Harris   +9 more
wiley   +1 more source

Isolated aneurysmal disease as an underestimated finding in individuals with JAG1 pathogenic variants

Human Mutation, Volume 43, Issue 12, Page 1824-1828, December 2022., 2022
Abstract Pathogenic variants in JAG1 are known to cause Alagille syndrome (ALGS), a disorder that primarily affects the liver, lung, kidney, and skeleton. Whereas cardiac symptoms are also frequently observed in ALGS, thoracic aortic aneurysms have only been reported sporadically in postmortem autopsies.
Jotte Rodrigues Bento, Alice Krebsová, Ilse Van Gucht, Irene Valdivia Callejon, An Van Berendoncks, Pavel Votypka, Ilse Luyckx, Petra Peldova, Steven Laga, Marek Havelka, Lut Van Laer, Pavel Trunecka, Nele Boeckx, Aline Verstraeten, Milan Macek, Josephina A. N. Meester, Bart Loeys   +16 more
wiley   +1 more source

Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage

European Journal of Neurology, Volume 30, Issue 1, Page 116-124, January 2023., 2023
Abstract Background and purpose Nuclear factor erythroid 2‐related factor 2 (NRF2; encoded by the NFE2L2 gene) has been implicated in outcome following aneurysmal subarachnoid haemorrhage (aSAH) through its activity as a regulator of inflammation, oxidative injury and blood breakdown product clearance.
Ben Gaastra, Poppy Duncan, Mark K. Bakker, Isabel C. Hostettler, Varinder S. Alg, Henry Houlden, Ynte M. Ruigrok, Ian Galea, Will Tapper, David Werring, Diederik Bulters   +10 more
wiley   +1 more source

The location of intraparenchymal bleeding determines functional outcome after spontaneous subarachnoid hemorrhage

European Journal of Neurology, Volume 30, Issue 2, Page 372-379, February 2023., 2023
Subarachnoid hemorrhage patients with hemorrhagic lesions of the corpus callosum (n = 6/280) are at an elevated risk of unfavorable 3‐month functional outcome. Abstract Background and purpose Non‐traumatic subarachnoid hemorrhage (SAH) is a devastating disease associated with high morbidity and mortality.
Anna Lindner, Stefan Kunst, Bogdan‐Andrei Ianosi, Verena Rass, Alois Josef Schiefecker, Mario Kofler, Victoria Limmert, Astrid E. Grams, Bettina Pfausler, Ronny Beer, Claudius Thomé, Raimund Helbok   +11 more
wiley   +1 more source

Small intracranial aneurysms of the anterior circulation: A negligible risk?

European Journal of Neurology, Volume 30, Issue 2, Page 389-398, February 2023., 2023
Abstract Background and purpose According to the International Study of Unruptured Intracranial Aneurysms, small (<7 mm) unruptured intracranial aneurysms (IAs) of the anterior circulation (aC) carry a neglectable 5‐year rupture risk. In contrast, some studies report frequencies of >20% of all ruptured IAs being small IAs of the aC.
Thiemo Florin Dinger, Jonas Peschke, Mehdi Chihi, Meltem Gümüs, Maryam Said, Alejandro Nicolas Santos, Jan Rodemerk, Anna Michel, Marvin Darkwah Oppong, Yan Li, Cornelius Deuschl, Karsten Henning Wrede, Philipp René Dammann, Benedikt Frank, Christoph Kleinschnitz, Michael Forsting, Ulrich Sure, Ramazan Jabbarli   +17 more
wiley   +1 more source

Thermally Drawn Shape and Stiffness Programmable Fibers for Medical Devices

Advanced Healthcare Materials, EarlyView.
Thermal drawing technique is adapted to fabricate Shape Memory Polymer Fibers (SMPFs) with programmable stiffness and shape. Multilumen and multimaterial SMPFs are developed for innovative medical devices: stiffness adjustable catheters, body temperature softening neural interfaces, and shape programmable cochlear implants.
Jiwoo Choi, Qindong Zheng, Mohamed E. M. K. Abdelaziz, Thomas Dysli, Daniel Bautista‐Salinas, Andreas Leber, Shan Jiang, Jianan Zhang, Ali Anil Demircali, Jinshi Zhao, Yue Liu, Nick W. F. Linton, Fabien Sorin, Xiaoting Jia, Eric M. Yeatman, Guang‐Zhong Yang, Burak Temelkuran   +16 more
wiley   +1 more source

Biomimetic Glycosaminoglycan‐Analog Hydrogel for Improved Embolization of Aneurysms: Environment‐Selective Swelling

Advanced Healthcare Materials, EarlyView.
Biomimetic glycosaminoglycan analog hydrogels exhibit suitable and robust mechanical properties, as well as hemocompatibility and biocompatibility, making them ideal for the embolization of intracranial aneurysms. Notably, the hydrogel's environment‐selective swelling properties enable complete blockage of the aneurysm cavity while preventing ...
Sarit S. Sivan, Iris Bonshtein, Maria Khoury, Yevgeniy Kreinin, Dmitry Korneyev, Tirosh Mekler, Sumaya Kaiyal, Iris Sonia Weitz, Netanel Korin   +8 more
wiley   +1 more source

Phenotype and surgical management of drug‐resistant epilepsy in patients with COL4A1 and COL4A2 variants

Epilepsia Open, EarlyView.
Abstract Objective To summarize the clinical features of collagen type IV alpha 1/2 chain (COL4A)1/2‐related epilepsy and the seizure outcomes of patients undergoing epilepsy surgery. Methods We retrospectively analyzed the clinical, electroencephalography, and neuroimaging data; genetic characteristics; surgical details; and prognosis of 8 patients (4
Jie Shi, Jiuluan Lin, Jianjun Bai, Haixiang Wang, Bingqing Zhang, Qian Feng, Zhaohui Sun, Yiou Liu, Jing He, Xiancheng Song, Siyu Wang, Xiaoyan Liu, Wenjing Zhou   +12 more
wiley   +1 more source