Results 71 to 80 of about 87,414 (288)

Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid‐Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Lipids, EarlyView.
ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao, Nuan Wang, Di Shi, Hao Zhou, Dan Chen, Guofang Chen   +5 more
wiley   +1 more source

Spontaneous subarachnoid haemorrhage due to coarctation of aorta and intraspinal collaterals : a rare presentation [PDF]

, 2012
The occurrence of spontaneous subarachnoid haemorrhage (SAH) in association with coarctation of thoracic aorta and absence of intracranial aneurysm is a rare association.
Devara, Anil K.V., Joseph, S., Uppu, S.C.   +2 more
core  

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. [PDF]

, 2018
OBJECTIVE: Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on ...
Ali, Muhammad S., Chalouhi, Nohra, Ding, Dale, Dumont, Aaron S., Hare, Joshua M., Hasan, David M., Jabbour, Pascal, Martinez Lege, Alejandra, Owens, Gary K, Pascale, Crissey L., Starke, Robert M., Thompson, John W., Toborek, Michal   +12 more
core   +2 more sources

Jointly Learned 3D Non‐Cartesian Sampling With Wave Encoding and Reconstruction for Neurovascular Phase Contrast MRI

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop accelerated 3D phase contrast (PC) MRI using jointly learned wave encoding and reconstruction. Methods Pseudo‐fully sampled neurovascular 4D flow data (N = 40) and a simulation framework were used to learn phase encoding locations, wave readout parameters, and model‐based reconstruction network (MoDL) for a rapid 3D PC scan (
Chenwei Tang, Brock W. Jolicoeur, James Rice, Caroline A. Doctor, Zaynab S. Yardim, Leonardo A. Rivera‐Rivera, Laura B. Eisenmenger, Kevin M. Johnson   +7 more
wiley   +1 more source

Kinematic measures provide useful information after intracranial aneurysm treatment [PDF]

, 2017
Introduction; Current methods of assessing the outcomes of intracranial aneurysm treatment for aneurysmal subarachnoid haemorrhage are relatively insensitive, and thus unlikely to detect subtle deficits.
Deniz, K, Goddard, T, Mon-Williams, M, Patankar, T, Raw, RK, Ross, SA, Wilkie, RM   +6 more
core   +1 more source

Persistent headache after aneurysmal subarachnoid hemorrhage: Prevalence, characteristics, and migraine history as a prognostic factor

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Persistent headache (PH) after an aneurysmal subarachnoid hemorrhage (aSAH) and the influence of migraine history (MH) on its evolution and prognosis is poorly understood. Our study aims are to (1) determine the prevalence, characteristics, and prognostic factors of PH after aSAH; and (2) study the impact of personal MH ...
Laura Gómez‐Dabó, Víctor J. Gallardo, Daniel Campos‐Fernández, Marc Rodrigo‐Gisbert, Maider Iza‐Achutegui, Anna Sánchez, Fuat Arikan, Estevo Santamarina, Edoardo Caronna, Patricia Pozo‐Rosich   +9 more
wiley   +1 more source

External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk [PDF]

Journal of Stroke, 2019
Background and Purpose Prediction of intracranial aneurysm growth risk can assist physicians in planning of follow-up imaging of conservatively managed unruptured intracranial aneurysms.
Mayte Sánchez van Kammen, Jacoba P. Greving, Satoshi Kuroda, Daina Kashiwazaki, Akio Morita, Yoshiaki Shiokawa, Toshikazu Kimura, Christophe Cognard, Anne C. Januel, Antti Lindgren, Timo Koivisto, Juha E. Jääskeläinen, Antti Ronkainen, Liisa Pyysalo, Juha Öhman, Melissa Rahi, Johanna Kuhmonen, Jaakko Rinne, Eva L. Leemans, Charles B. Majoie, W. Peter Vandertop, Dagmar Verbaan, Yvo B.W.E.M. Roos, René van den Berg, Hieronymus D. Boogaarts, Walid Moudrous, Ido R. van den Wijngaard, Laura ten Hove, Mario Teo, Edward J. St George, Katharina A.M. Hackenberg, Amr Abdulazim, Nima Etminan, Gabriël J.E. Rinkel, Mervyn D.I. Vergouwen   +34 more
doaj   +1 more source

Prostaglandin E-2-EP2-NF-kappa B signaling in macrophages as a potential therapeutic target for intracranial aneurysms [PDF]

, 2017
Intracranial aneurysms are common but are generally untreated, and their rupture can lead to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid hemorrhage, preventing the progression of intracranial aneurysms is ...
Aoki, Tomohiro, Bando, Kana, Frösen, Juhana, Fukuda, Miyuki, Laakkonen, Johanna, Narumiya, Shuh, Nozaki, Kazuhiko, Ollikainen, Eliisa, Shioi, Go, Tsuji, Keiichi   +9 more
core   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

Subarachnoid Haemorrhage in Malta : Are outcomes adversely affected due to lack of a local neurovascular service? [PDF]

, 2014
Objective: This study was performed to assess the incidence, treatment and outcome of non-traumatic Subarachnoid Haemorrhage (SAH) in an island which does not offer a neurovascular service and to determine whether such limitation is associated with a ...
Aquilina, Josanne, Dingli, Nicola, Galea Debono, Anthony, Vella, Malcolm, Vella, Norbert   +4 more
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