Intracranial-intracranial bypass is a crucial treatment for complex intracranial aneurysms, as it not only achieves aneurysm eradication but also ensures perfusion to the bypassed vascular territory.
JIN Ling-ji +3 more
doaj +1 more source
Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]
BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois +10 more
core +3 more sources
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi +18 more
wiley +1 more source
Spontaneous subarachnoid haemorrhage due to coarctation of aorta and intraspinal collaterals : a rare presentation [PDF]
The occurrence of spontaneous subarachnoid haemorrhage (SAH) in association with coarctation of thoracic aorta and absence of intracranial aneurysm is a rare association.
Devara, Anil K.V. +2 more
core
Intracranial Hemorrhage Due to Secondary Hypertension from Intracranial Large Vessel Occlusion [PDF]
Simultaneous hemorrhagic and ischemic strokes have been previously reported in the literature. Typically, these occur in patients secondary to dialysis, cerebral amyloid angiopathy, or thrombotic thrombocytopenic purpura.1,2,3 However, this is the unique
Khan, Asif A. +3 more
core
The “5L” framework of diagnostic reasoning: A stepwise scaffold to support clinician educators
Abstract Diagnostic reasoning (DR) is a core clinical skill, yet its teaching remains variable. We introduce the “5L” framework as a bedside teaching scaffold that gives educators and learners a shared, stepwise set of prompts for DR during individual encounters. By asking, “What's Lethal? What's Likely? What's Logical? What's Lurking?
Olivia Brumfield +3 more
wiley +1 more source
A Rapid and Computationally Inexpensive Method to Virtually Implant Current and Next-Generation Stents into Subject-Specific Computational Fluid Dynamics Models [PDF]
Computational modeling is often used to quantify hemodynamic alterations induced by stenting, but frequently uses simplified device or vascular representations.
Feinstein, Jeffrey A. +5 more
core +1 more source
This study investigated whether using a larger image matrix (1024 × 1024 pixels instead of 512 × 512) improves the visibility of tiny brain arteries on CT scans performed with standard 64‐slice scanners. While physical image quality measurements remained unchanged, the larger matrix provided finer digital sampling of blood vessel structures, resulting ...
Hokuto Nagumo +5 more
wiley +1 more source
Subarachnoid Haemorrhage in Malta : Are outcomes adversely affected due to lack of a local neurovascular service? [PDF]
Objective: This study was performed to assess the incidence, treatment and outcome of non-traumatic Subarachnoid Haemorrhage (SAH) in an island which does not offer a neurovascular service and to determine whether such limitation is associated with a ...
Aquilina, Josanne +4 more
core
This letter comments on Nagumo et al.'s study evaluating 1024‐matrix reconstruction for intracranial perforating artery visualisation in 64‐slice cerebral CTA, affirming its cost‐effective value for standard CT scanners (https://doi.org/10.1002/jmrs.70055).
Yang Liu, Wei Wu
wiley +1 more source

