Results 51 to 60 of about 48,119 (256)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

The application of intracranial ⁃ intracranial bypass for the treatment of complex intracranial aneurysms

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To explore the efficacy and safety of intracranial-intracranial bypass for the treatment of complex intracranial aneurysms. Methods and Results A total of 32 patients with complex intracranial aneurysms who were hospitalized for treatment at ...
SU Ying, LIU Pei-xi, SHI Yuan, LI Pei-liang, AN Qing-zhu, TIAN Yan-long, ZHU Wei   +6 more
doaj   +1 more source

Hypertension as a Determining Factor in the Rupture of Intracranial Aneurysms, Diagnosed by 64-MDCT Angiography

Makara Journal of Health Research, 2017
Background: To determine a correlation between risk factors and the rupture of intracranial aneurysms. Methods: A cross-sectional study of 29 patients with a saccular intracranial aneurysm was obtained using consecutive sampling and examination of 64 ...
Heni Fatmawati, Antonius G. Santoso
doaj   +1 more source

Automated detection of intracranial aneurysms using skeleton-based 3D patches, semantic segmentation, and auxiliary classification for overcoming data imbalance in brain TOF-MRA

Scientific Reports, 2023
Accurate and reliable detection of intracranial aneurysms is vital for subsequent treatment to prevent bleeding. However, the detection of intracranial aneurysms can be time-consuming and even challenging, and there is great variability among experts ...
Sungwon Ham, Jiyeon Seo, Jihye Yun, Yun Jung Bae, Tackeun Kim, Leonard Sunwoo, Sooyoung Yoo, Seung Chai Jung, Jeong-Whun Kim, Namkug Kim   +9 more
doaj   +1 more source

Jointly Learned 3D Non‐Cartesian Sampling With Wave Encoding and Reconstruction for Neurovascular Phase Contrast MRI

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop accelerated 3D phase contrast (PC) MRI using jointly learned wave encoding and reconstruction. Methods Pseudo‐fully sampled neurovascular 4D flow data (N = 40) and a simulation framework were used to learn phase encoding locations, wave readout parameters, and model‐based reconstruction network (MoDL) for a rapid 3D PC scan (
Chenwei Tang, Brock W. Jolicoeur, James Rice, Caroline A. Doctor, Zaynab S. Yardim, Leonardo A. Rivera‐Rivera, Laura B. Eisenmenger, Kevin M. Johnson   +7 more
wiley   +1 more source

Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association   +4 more
wiley   +1 more source

Causal relationship between telomere length and risk of intracranial aneurysm: a bidirectional Mendelian randomization study

Frontiers in Neurology
BackgroundTelomere length is closely linked to the aging phenotype, where cellular aging results in the production of a cascade of cell factors and the senescence-associated secretory phenotype (SASP), leading to an inflammatory response. The presence of
Bangjie Xu, Jiangbin Ren, Siqi Zhu, Yu Ding, Wei Zhou, Qing Guo, Yan Fang, Jing Zheng   +7 more
doaj   +1 more source

Persistent headache after aneurysmal subarachnoid hemorrhage: Prevalence, characteristics, and migraine history as a prognostic factor

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Persistent headache (PH) after an aneurysmal subarachnoid hemorrhage (aSAH) and the influence of migraine history (MH) on its evolution and prognosis is poorly understood. Our study aims are to (1) determine the prevalence, characteristics, and prognostic factors of PH after aSAH; and (2) study the impact of personal MH ...
Laura Gómez‐Dabó, Víctor J. Gallardo, Daniel Campos‐Fernández, Marc Rodrigo‐Gisbert, Maider Iza‐Achutegui, Anna Sánchez, Fuat Arikan, Estevo Santamarina, Edoardo Caronna, Patricia Pozo‐Rosich   +9 more
wiley   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI

Experimental Physiology, EarlyView.
Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley   +1 more source