Results 121 to 130 of about 4,351,134 (406)

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

open access: yesAdvanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao   +11 more
wiley   +1 more source

Intracranial hypertension in syndromic craniosynostosis:Prevalence, detection, pathophysiology and treatment [PDF]

open access: yes, 2023
This thesis highlights several aspects regarding the clinical course and treatment of syndromic craniosynostosis. First, we evaluate the prevalence of (syndromic) craniosynostosis: how many children are born with this rare condition in the Netherlands ...
den Ottelander, Bianca
core   +2 more sources

Review and recommendations on management of refractory raised intracranial pressure in aneurysmal subarachnoid hemorrhage

open access: yesVascular Health and Risk Management, 2013
Calvin Hoi Kwan Mak, Yeow Yuen Lu, George Kwok Chu Wong Department of Surgery, Prince of Wales Hospital, Shatin, Hong Kong Abstract: Intracranial hypertension is commonly encountered in poor-grade aneurysmal subarachnoid hemorrhage patients.
Mak CH, Lu YY, Wong GK
doaj  

Identifying stimulus-driven neural activity patterns in multi-patient intracranial recordings [PDF]

open access: yesarXiv, 2022
Identifying stimulus-driven neural activity patterns is critical for studying the neural basis of cognition. This can be particularly challenging in intracranial datasets, where electrode locations typically vary across patients. This chapter first presents an overview of the major challenges to identifying stimulus-driven neural activity patterns in ...
arxiv  

Achieving High‐Performance Transcranial Ultrasound Transmission Through Mie and Fano Resonance in Flexible Metamaterials

open access: yesAdvanced Science, EarlyView.
Transcranial ultrasound holds great potential in medical applications. However, effective transcranial ultrasound transmission remains challenging. To address these, this work introduces an innovative Mie‐resonance flexible metamaterial (MRFM), which consists of periodically arranged low‐speed micropillars embedded within a high‐speed flexible ...
Jie Chen   +11 more
wiley   +1 more source

Isolated aneurysmal disease as an underestimated finding in individuals with JAG1 pathogenic variants

open access: yesHuman Mutation, Volume 43, Issue 12, Page 1824-1828, December 2022., 2022
Abstract Pathogenic variants in JAG1 are known to cause Alagille syndrome (ALGS), a disorder that primarily affects the liver, lung, kidney, and skeleton. Whereas cardiac symptoms are also frequently observed in ALGS, thoracic aortic aneurysms have only been reported sporadically in postmortem autopsies.
Jotte Rodrigues Bento   +16 more
wiley   +1 more source

Nonlinear Schrödinger Kernel for hardware acceleration in machine learning inference [PDF]

open access: yesarXiv, 2020
Alternative machine learning approaches that are computationally light with low latency and can work with only a small training dataset are needed for applications where the insatiable demand of deep learning methods for computing power and large training data cannot be met.
arxiv  

RAISED INTRACRANIAL PRESSURE [PDF]

open access: yesJournal of Neurology, Neurosurgery & Psychiatry, 2002
Raised intracranial pressure (ICP) is a common problem in neurosurgical and neurological practice. It can arise as a consequence of intracranial mass lesions, disorders of cerebrospinal fluid (CSF) circulation, and more diffuse intracranial pathological processes. Its development may be acute or chronic.
openaire   +3 more sources

Intracranial Hypertension and Cerebral Perfusion Pressure Insults in Adult Hypertensive Intraventricular Hemorrhage: Occurrence and Associations With Outcome.

open access: yesCritical Care Medicine, 2019
OBJECTIVES Elevated intracranial pressure and inadequate cerebral perfusion pressure may contribute to poor outcomes in hypertensive intraventricular hemorrhage. We characterized the occurrence of elevated intracranial pressure and low cerebral perfusion
W. Ziai   +10 more
semanticscholar   +1 more source

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

open access: yesAdvanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao   +18 more
wiley   +1 more source

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