Results 91 to 100 of about 544,770 (251)

Venetoclax combined with cladribine, idarubicin, cytarabine (CLIA‐VEN) results in higher remission rates over conventional 7 + 3 chemotherapy without increased toxicity in newly diagnosed acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary Induction chemotherapy in fit de novo acute myeloid leukaemia (AML) patients has historically combined an anthracycline with standard‐dose cytarabine (‘7 + 3’) despite complete response (CR) rates of 50%–70%. In May 2023, our institution adopted the utilization of cladribine, cytarabine, idarubicin and venetoclax (CLIA‐VEN) for intensive ...
Benjamin J. Lee, Shawn P. Griffin, Jean Doh, Anthony Quach, Yujiao Sun, Piyatida Chumnumsiriwath, Stefan O. Ciurea, Jorge Ramos‐Perez, Polina Bellman, Deepa Jeyakumar, Piyanuch Kongtim, Kiran Naqvi   +11 more
wiley   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Cerebral venous sinus thrombosis

Journal of Thrombosis and Haemostasis, 2018
The cerebral venous system is an unusual site of thrombosis, with a particularly high incidence in young adults. This incidence has increased in past decades because of the improvement of neuroradiological techniques.
M. Capecchi, M. Abbattista, I. Martinelli   +2 more
semanticscholar   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Correction to: Features of intracranial hemorrhage in cerebral venous thrombosis [PDF]

, 2020
K. Afifi, Guillaume Bellanger, P.-J. Buyck, Susanna M. Zuurbier, Carlos García-Esperón, Miguel A. Barboza, Paolo Costa, Irene Escudero‐Martínez, Dimitri Renard, Robin Lemmens, Nicole Hinteregger, Franz Fazekas, Jordi Jiménez‐Conde, Eva Giralt‐Steinhauer, Sini Hiltunen, Antonio Araúz, Alessandro Pezzini, Joan Montaner, Jukka Putaala, Christian Weimar, Marc Schlamann, Thomas Gattringer, Turgut Tatlisumak, Jonathan M. Coutinho, Philippe Demaerel, Vincent Thijs   +25 more
openalex   +1 more source

Beyond BMI: Practical Guide for Clinicians to Integrate the Lancet Commission's Obesity Framework and King's Obesity Staging System

Clinical Obesity, EarlyView.
ABSTRACT Body mass index (BMI) on its own is a poor diagnostic and staging tool for obesity because it does not measure health status. The newly published Lancet Clinical Obesity Criteria (LCOC) for defining clinical obesity distinguish preclinical and clinical obesity based on organ or tissue dysfunction.
Tak Ying Louise Ko, Alexander D. Miras, Dimitri J. Pournaras, Carel W. Le Roux   +3 more
wiley   +1 more source

Acute Mastoiditis Complicated with Concomitant Bezold’s Abscess and Lateral Sinus Thrombosis

Case Reports in Otolaryngology, 2018
Bezold’s abscess is a very rare extracranial complication of acute mastoiditis. Lateral sinus thrombosis is another intracranial complication of acute mastoiditis that can occur, but there are only few reports of concomitant ispilateral Bezold’s abscess ...
Aziz Mustafa, Burhan Toçi, Hajdin Thaçi, Bujar Gjikolli, Nehat Baftiu   +4 more
doaj   +1 more source

Spontaneous Intracranial Hypotension Complicated by Cerebral Venous Thrombosis Relieved by Epidural Blood Patch [PDF]

, 2019
Young Ik Jung, Byung‐Su Kim, Junghee Seo, Hee Jin Lee, Hyun‐Jeung Yu, Eun Hye Jeong, Mun-Kyung Sunwoo, Yun Kyung Park   +7 more
openalex   +1 more source

Posttraumatic delayed cerebral venous thrombosis with thrombocytopenia leading to multiple delayed intracranial hemorrhage

, 2023
Yu Shi, Kai Chen, Yihang Sui, Changren Huang   +3 more
openalex   +1 more source

Neonates born at term with periventricular haemorrhagic infarction: Risk factors and clinical presentation

Developmental Medicine &Child Neurology, EarlyView.
This case series describes infants born near term with periventricular hemorrhagic infarction (PVHI), highlighting seizures as a common early symptom. Neonatal complications during delivery and pro‐thrombotic genetic mutations were slightly more common. MRI‐classified involvement was predominantly in the caudate vein territory.
Aleksandra Zaykova, Jeroen Dudink, Floris Groenendaal, Maarten H. Lequin, Manon J.N.L. Benders, Maria Luisa Tataranno, Elise Roze   +6 more
wiley   +1 more source