Results 21 to 30 of about 36,202 (238)

Multiple myeloma with intractable lumbar pain and diagnostic challenge with MRI: A case report

open access: yesRadiology Case Reports, 2021
We present a 63-year-old male patient with intractable bone pain and rapidly progressive osteoporosis, who was diagnosed with multiple myeloma (MM) by CT despite normal magnetic resonance imaging (MRI) findings.
Min Jae Myung, MD   +4 more
doaj   +1 more source

Ketamine Use for Successful Resolution of Post-ERCP Acute Pancreatitis Abdominal Pain

open access: yesCase Reports in Anesthesiology, 2017
We report a case in which a patient with intractable pain secondary to post-endoscopic retrograde cholangiopancreatography (ERCP) acute pancreatitis is successfully treated with a subanesthetic ketamine infusion.
Suneel M. Agerwala   +2 more
doaj   +1 more source

Perspectives on emotional memory images and the persistence of pain

open access: yesFrontiers in Pain Research, 2023
Multiple influences prevent recovery from pain. Our viewpoint is that non-conscious emotional memory images (EMIs) triggers outdated stress responses contributing to the intractability of pain.
Matt Hudson   +2 more
doaj   +1 more source

Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer Patients

open access: yesPalliative Medicine Reports, 2021
Background: There are no universal tools to predict the necessity of high-dose opioid use for cancer-related pain. Early recognition and interventions for intractable cancer pain could minimize the distress of palliative patients. Objective: We sought to
Hidetoshi Sumimoto   +9 more
doaj   +1 more source

Introduction: Intractable pain [PDF]

open access: yesNeurosurgical Focus, 2013
The problem of surgical pain management remains one of the most daunting in our specialty. Traditionally, we divide the surgical approaches into the more historic destructive procedures (“ablative”) and the more contemporary modulatory ones (stimulation or intrathecal agents).
Ashwin Viswanathan, Kim J. Burchiel
openaire   +1 more source

Successful Management of Refractory Headache and Facial Pain due to Cavernous Sinus Meningioma with Sphenopalatine Ganglion Radiofrequency

open access: yesCase Reports in Neurological Medicine, 2014
Headaches and facial pain can be extremely difficult to manage for the patient and the clinician. In the medical literature, it has been suggested that the autonomic reflex plays an important role in the pathophysiology of facial neuralgia.
Foad Elahi, Kwo Wei David Ho
doaj   +1 more source

Ultrasound-Guided Nerve Block with Botulinum Toxin Type A for Intractable Neuropathic Pain

open access: yesToxins, 2016
Neuropathic pain includes postherpetic neuralgia (PHN), painful diabetic neuropathy (PDN), and trigeminal neuralgia, and so on. Although various drugs have been tried to treat neuropathic pain, the effectiveness of the drugs sometimes may be limited for ...
Young Eun Moon   +4 more
doaj   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

open access: yesAdvanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang   +8 more
wiley   +1 more source

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

open access: yesAdvanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang   +11 more
wiley   +1 more source

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

open access: yesAnnals of Neurology, EarlyView.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov   +42 more
wiley   +1 more source

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