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A Novel Technique for Intradermal Delivery of Drugs – Coated Polymeric Needles

Research Journal of Topical and Cosmetic Sciences, 2021
The barrier properties of the topmost layer of the skin, stratum corneum have significant limitations for successful systemic delivery of a wide range of therapeutic molecules, especially macromolecules and genetic material. One solution is to utilize microneedles (MNs), which are capable of painlessly traversing through the stratum corneum and ...
A. Lakshmi Usha   +3 more
openaire   +1 more source

A new compound curved needle for intradermal suture closure

The Journal of Emergency Medicine, 1989
A new compound curved needle has been designed and developed for intradermal suture closure from a unique stainless steel alloy, American Society of Testing Materials (ASTM) 45500. This needle has a short, straight, sharpened point with a reverse cutting edge, followed by a curved distal section.
M R, Abidin   +6 more
openaire   +2 more sources

Intradermal needle-free powdered drug injection by a helium-powered device

2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2012
We present a new method for needle-free powdered drug injection via a bench-top gas-powered device. This injector provides an alternative method of vaccine delivery to address the cold chain problem--the cost and risk of transporting temperature sensitive vaccines to developing countries. The device houses interchangeable nozzle inserts to vary orifice
John, Liu   +2 more
openaire   +2 more sources

Insertion of Intradermal Needles Into Painful Points Provides Analgesia for Intractable Abdominal Scar Pain

Regional Anesthesia and Pain Medicine, 2001
Conventional treatments are often ineffective for patients having painful abdominal scars. There are painful points in and around scar tissue. We tested the hypothesis that insertion of intradermal needles into these painful points reduces scar pain.Patients with abdominal scar pain with painful points that is not relieved by conventional treatments ...
N, Kotani   +5 more
openaire   +2 more sources

Intradermal immunization with novel plasmid DNA-coated nanoparticles via a needle-free injection device

Journal of Biotechnology, 2003
A high population of dendritic cells in the skin makes intradermal (ID) immunization an attractive route. We sought to further enhance immune responses from a previously reported novel nanoparticle-based DNA vaccine delivery system by administering the system intradermally into mouse skin using Biojector 2000, a needle-free jet injection device.
Zhengrong, Cui   +2 more
openaire   +2 more sources

Clinical study on intradermal needle therapy in treating urinary retention after cervical cancer surgery

Journal of Acupuncture and Tuina Science, 2020
To observe the clinical efficacy of intradermal needle therapy for urinary retention after cervical cancer surgery. A total of 100 patients with urinary retention after cervical cancer surgery were randomized into a control group and an observation group, with 50 cases in each group.
Xuan-xuan Zhu, Chang-zheng Wu, Min Bao
openaire   +1 more source

A study to assess the intradermal, triangular needle and bifurcated needle techniques in the administration of BCG to newborns

Tubercle, 1975
BCG at birth was administered to 3,297 new born babies in Hong Kong using the intradermal, simple triangular and bifurcated needle techniques. Tuberculin testing at 3 months showed similar mean reactions for the intradermal and simple triangular needle methods, namely 9-74 mm and 9-87 mm with 9-94 mm for the triangular needle method when the BCG ...
openaire   +2 more sources

[Intradermal needling combined with heat-sensitive moxibustion for moderate to severe cancer pain].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2021
To observe the effect of intradermal needling combined with heat-sensitive moxibustion for moderate to severe cancer pain.A total of 60 patients with moderate to severe cancer pain were randomly divided into an observation group and a control group,30 cases in each one.
Jin-Feng, Ji   +8 more
openaire   +1 more source

[Effects of intradermal needling combined with tuina on ankle sprain sequelae].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2019
To compare the clinical efficacy differences between intradermal needling combined with tuina and tuina alone on ankle sprain sequelae.Ninety patients with chronic ankle sprain were randomly divided into an observation group and a control group, 45 cases in each group. The patients in the control group were treated with conventional tuina. The patients
Yang, Yang   +4 more
openaire   +1 more source

WITHDRAWN: Coated polymeric needles for rapid and deep intradermal delivery

International Journal of Pharmaceutics, 2020
Álvaro, Cárcamo-Martínez   +5 more
openaire   +2 more sources

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