Results 141 to 150 of about 144,436 (251)

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

Molecular Carcinogenesis, Volume 65, Issue 9, Page 1052-1062, September 2026.
ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh, Eun‐Ryeong Hahm, Bruce L. Jacobs, Shivendra V. Singh   +3 more
wiley   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

Penile intraepithelial neoplasia: results of photodynamic therapy

, 2006
Failure of response to treatment or recurrent disease is often noted in patients with penile intraepithelial neoplasia. Photodynamic therapy has recently been added to the list of treatment modalities used for this diagnosis. Our primary objective was to
Paoli, John,, Ternesten Bratel, A., Stenquist, Bo,, Wennberg, Ann-Marie,, Löwhagen, Gun-Britt,, Forslund, O.   +5 more
core  

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours

The Journal of Pathology, Volume 270, Issue 1, Page 4-22, September 2026.
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal, Elizabeth A Montgomery, Alexandros D Polydorides, Anthony J Gill, Motohiro Kojima, Mark J Arends   +5 more
wiley   +1 more source

Comparison of Cervical Screening at 6‐ and 12‐Weeks Postnatal: A Paired‐Sample Feasibility Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 10, Page 1857-1865, September 2026.
ABSTRACT Objective Feasibility of a paired‐sample study comparing cervical screening and urine self‐sampling at 6‐ and 12‐weeks postnatal. Design Paired‐sample feasibility study. Setting Acute hospital. Population or Sample Females within 6 weeks of childbirth. Methods Paired‐sample study comparing cervical screening and high‐risk human papillomavirus (
Victoria A. Cullimore, Tessa Dean, Kim Chu, Adam Brentnall, Karin Denton, Katherine Hunt, Alexandra Sargent, Laura Johns, Katharine Edey, Sarah L. Coleridge, Jane Borley, Rebecca Newhouse, Holly Baker‐Rand, Lorna McWilliams, Emma J. Davidson, Jo Morrison   +15 more
wiley   +1 more source

Balancing diagnostic accuracy and cost in the follow‐up of histological low‐grade squamous intraepithelial lesions

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 9, Page 1871-1878, September 2026.
Primary follow‐up of histological LSIL can shift from colposcopy to liquid‐based co‐testing without missed cancers, as the incremental cost per additional HSIL+ detected is unjustified. Abstract Introduction Primary cervical screening with testing for human papillomavirus (HPV) brings increased detection of women with low‐grade squamous intraepithelial
Riina Aarnio, Vasudha Ahuja, Linda Ryen, Lovisa Bergengren   +3 more
wiley   +1 more source

HPV Genotype Distribution and Its Anatomical Site Specificity in Vaginal Intraepithelial Neoplasia. [PDF]

J Med Virol
Chen J, Chen X, Lin X, Wang Y, Ye P, Hou L, Chen X.   +6 more
europepmc   +1 more source

Bile‐Derived Exosomal miR‐196a/‐196b as Diagnostic Biomarkers Associated With Tumor Progression in Biliary Tract Cancer

Cancer Science, Volume 117, Issue 9, Page 2521-2534, September 2026.
Bile‐derived exosomal miR‐196a and miR‐196b are identified as novel biomarkers for biliary tract cancer. Serum miR‐196a levels are significantly elevated in advanced disease with metastasis, while both miRNAs contribute to tumor progression by promoting cancer cell proliferation and invasion.
Naotaka Kugiyama, Katsuya Nagaoka, Takehisa Watanabe, Michihiro Yoshida, Tadashi Toyohara, Cheng Pan, Kenyu Hashimoto, Fumiya Otsuka, Shinya Ushijima, Yukiko Uramoto, Hajime Iwasaki, Motohiro Yoshinari, Shunpei Hashigo, Kazuki Hayashi, Itaru Naitoh, Fumihiro Okumura, Hiromu Kondo, Kaiki Anbe, Hiromitsu Hayashi, Yoshihiro Komohara, Yasuhito Tanaka   +20 more
wiley   +1 more source