Results 151 to 160 of about 130,124 (257)

Balancing diagnostic accuracy and cost in the follow‐up of histological low‐grade squamous intraepithelial lesions

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 9, Page 1871-1878, September 2026.
Primary follow‐up of histological LSIL can shift from colposcopy to liquid‐based co‐testing without missed cancers, as the incremental cost per additional HSIL+ detected is unjustified. Abstract Introduction Primary cervical screening with testing for human papillomavirus (HPV) brings increased detection of women with low‐grade squamous intraepithelial
Riina Aarnio, Vasudha Ahuja, Linda Ryen, Lovisa Bergengren   +3 more
wiley   +1 more source

Bile‐Derived Exosomal miR‐196a/‐196b as Diagnostic Biomarkers Associated With Tumor Progression in Biliary Tract Cancer

Cancer Science, Volume 117, Issue 9, Page 2521-2534, September 2026.
Bile‐derived exosomal miR‐196a and miR‐196b are identified as novel biomarkers for biliary tract cancer. Serum miR‐196a levels are significantly elevated in advanced disease with metastasis, while both miRNAs contribute to tumor progression by promoting cancer cell proliferation and invasion.
Naotaka Kugiyama, Katsuya Nagaoka, Takehisa Watanabe, Michihiro Yoshida, Tadashi Toyohara, Cheng Pan, Kenyu Hashimoto, Fumiya Otsuka, Shinya Ushijima, Yukiko Uramoto, Hajime Iwasaki, Motohiro Yoshinari, Shunpei Hashigo, Kazuki Hayashi, Itaru Naitoh, Fumihiro Okumura, Hiromu Kondo, Kaiki Anbe, Hiromitsu Hayashi, Yoshihiro Komohara, Yasuhito Tanaka   +20 more
wiley   +1 more source

Cervical Cytokine Profile in High‐Grade Squamous Intraepithelial Lesions

Cytopathology, Volume 37, Issue 5, Page 523-530, September 2026.
Hypothetical mechanism of immune modulation in HSIL associated with high‐risk HPV infection, based on observed cytokine suppression. The diagram illustrates impaired Th1 responses, reflected by reduced production of IL‐2 and TNF, which may compromise the activation and cytotoxic function of CD8+ T cells and NK cells, facilitating immune evasion.
Talles Henrique de Araújo Pontes, Amaxsell Thiago Barros de Souza, Carolina de O. Mendes‐Aguiar, Maria do Perpétuo Socorro Nobre Medeiros e Silva, Juliana Dantas de Araújo Santos Camargo, George Alexandre Lira, Ricardo Ney Cobucci, Deyse de Souza Dantas, Janaina Cristiana de Oliveira Crispim   +8 more
wiley   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, Volume 89, Issue 3, Page 442-455, September 2026.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

Spatial transcriptomics reveals clonal relationships between intraductal carcinoma and adjacent invasive prostate cancer

Histopathology, Volume 89, Issue 3, Page 429-441, September 2026.
Spatial transcriptomics of six prostate samples reveals a close clonal relationship between high‐grade Prostatic Intraepithelial Neoplasia (HGPIN), Intraductal carcinoma (IDC) and adjacent invasive glands. In three samples, adjacent invasive glands had more copy number variants than HGPIN and IDC. Adjacent invasive glands were also placed at the end of
Hridya Harikumar, Myrthe de Waard‐van Baardwijk, Marit de Haan, Gregory van Beek, Karishma Lila, Martin E van Royen, Thierry PP van den Bosch, Mathijs A Sanders, Eric Bindels, Andrew Stubbs, Geert JLH van Leenders   +10 more
wiley   +1 more source

Risk stratification and anal cancer screening in immunocompetent women with genital HPV: Value of multicentric HSIL and performance of HPV‐based screening

International Journal of Cancer, Volume 159, Issue 4, Page 1017-1027, 15 August 2026.
What's new? Anal squamous cell carcinoma (ASCC) incidence is increasing, with most cases occurring in immunocompetent women. ASCC risk is linked in particular to genital human papillomavirus (HPV) infection and HPV‐associated high‐grade squamous intraepithelial lesions (HSILs).
Isabel Matas, Aureli Torné, Adela Saco, Cristina Martí, Ada Cardiel, Natalia Rakislova, Lorena Marimon, Ariel Glickman, Ingrid Victoria, Silvia Alós, Jesús Lopez‐Diaz, Pere Fusté, Jaume Ordi, Marta del Pino   +13 more
wiley   +1 more source

Effective Management of Recurrent Conjunctival Intraepithelial Neoplasia Using Topical Mitomycin C 0.02. [PDF]

Cureus
Alnafisah HA, Alshaibani MH, AlOmairini MI.   +2 more
europepmc   +1 more source

Nationwide Study on the Cervical Cancer Screening Pathway in Estonia

International Journal of Cancer, Volume 159, Issue 4, Page 883-895, 15 August 2026.
Cervical cancer remains a significant burden despite being preventable, largely due to inadequate screening participation and poor follow‐up of high‐risk women. Here, the authors investigated follow‐up rates among women who tested positive for high‐risk human papillomavirus (hr‐HPV) infection in primary screening in Estonia. Data show that more than 57
Aleksandra Šavrova, Helen Jakoby, Anna Tisler, Kaire Innos, Ülo Maiväli, Jana Jaal, Anneli Uusküla   +6 more
wiley   +1 more source

Detection of HPV DNA in Cervical Intraepithelial Neoplasia Using In Situ Hybridization. [PDF]

J Clin Med
Przybylski M, Millert-Kalińska S, Pruski D, de Mezer M, Krzyżaniak M, Jach R, Żurawski J, Kurzawa P.   +7 more
europepmc   +1 more source

Recent treatment outcomes of cervical intraepithelial neoplasia in south western Uganda: a six year retrospective study. [PDF]

Gynecol Oncol Rep
Ssedyabane F, Kajabwangu R, Mudondo H, Tusubira D, Muhumuza J, Namuli A, Mwesigwa G, Bagenda CN, Castro CM, Lee H, Randall TC, Ngonzi J.   +11 more
europepmc   +1 more source