Results 41 to 50 of about 61,704 (279)

Prostate biopsies containing prostate intraepithelial neoplasia and atypical small acinar proliferation: what to do? [PDF]

Einstein (São Paulo), 2009
Objective: The aim of the study was to assess the frequency of high-grade prostate intraepithelial neoplasia and atypical small acinar proliferations on a contemporary series, and their relation to posterior diagnosis of prostate cancer.
Fernando Korkes, Suellen Ka Gi Mo, Cristiane Sayuri Koza de Jesus, Marilia Germanos Castro   +3 more
doaj  

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Clinical analysis of cervical intraepithelial neoplasia with vaginal intraepithelial neoplasia

Medicine, 2017
The purpose of this prospective cohort study is to evaluate the importance of screening and its diagnostic accuracy compared with the pathological diagnosis of cervical intraepithelial neoplasia (CIN) with vaginal intraepithelial neoplasia (VAIN).The prospective study enrolled 419 patients (pts) and was conducted between February 1, 2015 and January 31,
He, Yue, Zhao, Qun, Geng, Yu-Ning, Yang, Shu-Li, Yin, Cheng-Hong, Wu, Yu-Mei   +5 more
openaire   +2 more sources

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Meta-analysis about correlation between the human Papillomavirus infection and the incidence of cervical intraepithelial Neoplasia

Journal of the Pakistan Medical Association
Objective: To determine the correlations between human papillomavirus infection and the incidence of cervical intraepithelial neoplasia. Method:This study was conducted in the Affiliated Hospital of Zunyi Medical University, Zunyi, China in January 2024.
Mingyang Wang, Xiaofeng Zou, Zhiliang Wang   +2 more
doaj   +1 more source

Esophageal low-grade intraepithelial neoplasia overlying multiple leiomyomas: A case report and review of the literature

Frontiers in Oncology, 2022
BackgroundEsophageal leiomyoma is the most common benign submucosal mesenchymal tumor. Esophageal intraepithelial neoplasia includes low-grade and high-grade intraepithelial neoplasia. The coexistence of epithelial lesions and the subepithelial lesion is
Wen Pan, Wen Pan, Junchao Wu, Chao Liu, Yanjun He, Jinlin Yang   +5 more
doaj   +1 more source

Can molecular markers stratify the diagnostic value of high-grade prostatic intraepithelial neoplasia?

, 2011
The diagnostic performance of isolated high-grade prostatic intraepithelial neoplasia in prostatic biopsies has recently been questioned, and molecular analysis of high-grade prostatic intraepithelial neoplasia has been proposed for improved prediction ...
Gasser, Thomas C., Bachmann, Alex, Tobias Zellweger, Zlobec, Inti, Alex Bachmann, Thomas C. Gasser, Bubendorf, Lukas, Jürg Vosbeck, Seife Hailemariam, Inti Zlobec, Lukas Bubendorf, Mattarelli, Gianfranco, Gieri Cathomas, Cathomas, Gieri, Vosbeck, Jürg, Gasser, Thomas C, Tobias Eichenberger, Hailemariam, Seife, Eichenberger, Tobias, Gianfranco Mattarelli, Zellweger, Tobias   +20 more
core   +1 more source

In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review

Translational Oncology, 2021
Neoplasia of the cervix represents one of the most common cancers in women. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients.
Yenddy N. Carrero, Diana E. Callejas, Jesús A. Mosquera   +2 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source