Results 41 to 50 of about 23,666 (230)

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Comparative finite element analysis: internal fixation plate versus intramedullary nail for neer type III-VI proximal humeral fractur

Journal of Orthopaedic Surgery and Research
Background Finite element analysis (FEA) could advance the understanding of fracture fixation and guide the choice of surgical treatment. This study aimed to compare two internal fixation methods in the treatment of displaced proximal humeral fracture ...
Yan Shi, Junlin Zhou
doaj   +1 more source

Safety and efficacy of surgical fixation of fibula fractures using an intramedullary nail: a retrospective observational cohort study in 30 patients

Patient Safety in Surgery, 2019
Background Open reduction and internal fixation remains the standard treatment for displaced unstable ankle fractures. Plate fixation represents the most frequently used instrumentation option in fibula fractures and favourable outcomes have been ...
Guilherme Boni, Gustavo T. Sanchez, Gustavo Arliani, Boris A. Zelle, Robinson E. Pires, Fernando B. dos Reis   +5 more
doaj   +1 more source

Percutaneous leverage technique for reduction of radial neck fractures in children: Technical tips

Journal of Children's Orthopaedics, 2020
Purpose Paediatric radial neck fractures are challenging to treat. Multiple strategies exist for reduction and fixation; there is no clear consensus on the best surgical technique to achieve reduction.
Colyn J. Watkins, Caleb M. Yeung, Emily Rademacher, Dennis E. Kramer   +3 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source

Arthroscopic Bicortical Biceps Anchorage: An Arthroscopic‐Assisted Technique for Subpectoral Biceps Tenodesis

Arthroscopy Techniques, EarlyView.
Abstract Long head of the biceps tendon pathology is a frequent cause of anterior shoulder pain. Tenotomy is technically simple but may lead to cosmetic deformity and muscle cramping, whereas tenodesis better preserves the biceps contour but involves a more complex procedure. Multiple surgical techniques and fixation methods are available.
Gert‐Jan Opsomer, Ludwig Anné, Olivier Verborgt   +2 more
wiley   +1 more source

Concomitant bent and broken intramedullary nail in the femoral fracture: A case report and review of literature

Journal of Orthopaedic Reports, 2022
Background: Bent or broken intramedullary nail in femoral fracture fixation is a rare complication but challenging. The purpose of this paper is to present the combination of these rare situation and review the literature to manage this challenging ...
Pongsakorn Rungchamrussopa, Chittawee Jiamton, Theerachai Apivatthakakul   +2 more
doaj   +1 more source

Intramedullary Nailing Versus External Fixation in the Treatment of Open Tibial Fractures in Tanzania [PDF]

, 2020
BACKGROUND: Open tibial fractures are common injuries in low and middle-income countries, but there is no consensus regarding treatment with intramedullary nailing versus external fixation.
Eliezer, Edmund N, Albright, Patrick, Challa, Sravya T, Morshed, Saam, David W. Shearer, Billy T. Haonga, Ali, Syed H, Max Liu, Shearer, David W, Sravya T. Challa, Edmund N. Eliezer, Haonga, Billy T, Syed H. Ali, Liu, Max, Lazar, Ann A, Patrick Albright, Ann A. Lazar, Saam Morshed   +17 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source