Results 41 to 50 of about 6,422 (132)

Expedient synthesis of 1,6-anhydro-α-D-galactofuranose, a useful intermediate for glycobiological tools [PDF]

, 2014
A new and efficient three-step procedure for the synthesis of 1,6-anhydro-α-D-galactofuranose is described. The key step involves the formation of the galactofuranosyl iodide by treatment of per-O-TBS-D-Galf with TMSI, the selective 6-O-desilylation by ...
Baldoni, Luciana, Marino, María Carla
core   +2 more sources

Recent Advances in Metal‐Organic Framework‐Integrated Nanocomposite Hydrogels for Sensors and Sensing Systems

SmartMat, Volume 7, Issue 1, February 2026.
Metal‐organic framework–hydrogel composites are explored as multifunctional materials for next‐generation sensors and sensing systems. This review summarizes recent advances in employing these smart composites to fabricate optical, electrochemical, and electromechanical sensors, emphasizing their potential in healthcare, biomedical diagnostics ...
Md Sazzadur Rahman, Emna Helal, Nicole R. Demarquette   +2 more
wiley   +1 more source

EC-BLAST: a tool to automatically search and compare enzyme reactions. [PDF]

, 2014
We present EC-BLAST (http://www.ebi.ac.uk/thornton-srv/software/rbl/), an algorithm and Web tool for quantitative similarity searches between enzyme reactions at three levels: bond change, reaction center and reaction structure similarity.
A Dalby, A Theocharidis, AL Cuff, C Jochum, C Steinbeck, DARSD Latino, F Mu, Gemma L Holliday, I Ugi, J Lees, J-L Faulon, Janet M Thornton, K Tipton, L Chen, M Kanehisa, M Kotera, M Leber, Nicholas Furnham, NM O'Boyle, NM O'Boyle, Q-Y Zhang, RHS Thompson, RS Cahn, S Heller, SA Rahman, SA Rahman, Sergio Martinez Cuesta, Syed Asad Rahman, T Sing, V Egelhofer, V Prelog, WL Chen, Y Yamanishi   +32 more
core   +3 more sources

Deprotective Functionalization: An Emerging Concept for Amine Reactivity

Chemistry – A European Journal, Volume 32, Issue 4, 23 January 2026.
While protecting groups are indispensable in total synthesis to avoid undesired reactivity, installation and removal of protecting groups lead to an increase in the step‐count, cost, waste production and time requirement. One approach tackling these drawbacks is deprotective functionalization, which combines deprotection and postfunctionalization in a ...
Irmgard Tiefenbrunner, Saad Shaaban, Nuno Maulide   +2 more
wiley   +1 more source

K-Ras protein as a drug target [PDF]

, 2016
K-Ras proteins are major drivers of human cancers, playing a direct causal role in about one million cancer cases/year. In cancers driven by mutant K-Ras, the protein is locked in the active, GTP-bound state constitutively, through a defect in the off ...
Frank McCormick
core   +2 more sources

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation [PDF]

, 2013
Advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs) have a pathogenetic role in the development and progression of different oxidative-based diseases including diabetes, atherosclerosis, and neurological disorders.
A. Cipak, Abraham K, Abraham K, Adamiec J, Alary J, Aldini G, Amadori M, Andrewes P, Arntz D, Avzianova E, Balogh LM, Baumgart T, Baynes JW, Bechara EJH, Bein K, Beisswenger PJ, Biemel KM, Biemel KM, Biemel KM, Bondoc FY, Breyer V, Bunn HF, Butterfield DA, Callingham BA, Camel V, Cammerer B, Carmella SG, Casazza JP, Catala A, Cho SJ, Choi CH, Choudhary V, Ciulla MM, Collard F, Cooper R, Cooper RA, Cotham WE, Cui Q, D. De Maddis, Dai ZY, Davidek T, Davies SS, Degen J, Degenhardt TP, Del Rio D, Delpierre G, Dhar A, Dills WL, Doorn JA, Doureradjou P, Dunkerton J, Dyer DG, Eisner BH, Erbersdobler HF, Esterbauer H, Fan XJ, Franke S, Fu MX, Fu TM, Fujioka K, Furuhata A, G. Aldini, G. Vistoli, Garzon B, Geissler S, Gensberger S, Glomb MA, Glomb MA, Gobert J, Goh S-Y, Grandhee SK, Guéraud F, Hamada Y, Hartkopf J, Hayase F, Hellwig M, Henle T, Henle T, Henle T, Hermetter A, Heyns K, Hidalgo FJ, Hodge J, Hoff HF, Hollnagel A, HomokiFarkas P, Huber J, Iacobini C, Iijima K, Isbell H, Ishii T, Ishii T, Jadhav H, Jaganjac M, Jono T, Jung JY, Kalapos M, Kalapos MP, Kalapos MP, Karachalias N, Kielhorn J, Klopfer A, Krause R, Kroh LW, Kuiper HC, Kunkel HG, Kuntz S, Kurata T, Kurien BT, Lal S, Lange JN, Laroque D, Lederer MO, Li JL, Lin D, Linden T, Liu L, Liu ZF, Lo TWC, Long EK, LoPachin RM, LoPachin RM, Luevano-Contreras C, M. Carini, Maeshima T, Maillard L, Manini P, Mannervik B, Meade SJ, Mittelmaier S, Miyata S, Monnier VM, Montuschi P, Morales FJ, Munoz-Clares RA, N. Zarkovic, Nagaraj RH, Nagaraj RH, Namiki M, Nasiri R, Nasiri R, Nasiri R, Negre-Salvayre A, Nemet I, Nemet I, Nemet I, Niki E, Nishibori S, Niwa H, Niwa T, Niwa T, Nursten H, Obayashi H, Ortiz A, Ota M, Oya T, Pamplona R, Pamplona R, Pfeifer YV, Rabbani N, Ramasamy R, Reihl O, Reihl O, Requena JR, Rippe JM, Sakai M, Salomon RG, Schalkwijk CG, Schalkwijk CG, Schwarzenbolz U, Schwarzenbolz U, Sebekova K, Seiler N, Sell DR, Sell DR, Sell DR, Sell DR, Shangari N, Shibata T, Shipanova IN, Silva AMN, Sjoberg JS, Skovsted IC, Slatter DA, Slaughter JC, Spiteller P, Stevens JF, Sugiyama S, Suárez G, Szori M, Talhout R, Tessier F, Tessier FJ, Thornalley PJ, Thornalley PJ, Thornalley PJ, Thornalley PJ, Tsukushi S, Turk Z, Uchida K, Uchida K, Van Lancker F, Vander Jagt DL, Vander Jagt DL, Vedantham S, Wang HY, Wang TN, Wang Y, Wang Y, Wellsknecht KJ, Wellsknecht KJ, Westwood ME, Yamagishi S, Yang K, Yap FYT, Yin HY, Zeitsch K, Zeng JM, Zhang M, Zhu XC   +219 more
core   +1 more source

Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy

Advanced Materials, Volume 38, Issue 3, 13 January 2026.
Weakly assembled peptide amphiphile nanostructures disassemble in circulation and reassemble with blood biomolecules, mainly lipoproteins. Binding to blood biomolecules prolongs blood circulation and improves accumulation in solid tumors. In the tumor microenvironment, peptide amphiphiles assemble with cholesterol‐rich domains of cell membranes ...
Li Xiang, Morgan R. Stewart, Kailin Mooney, Mingchong Dai, Samuel Drennan, Samantha Holland, Arnaud Quentel, Sinan Sabuncu, Benjamin R. Kingston, Isabel J. Dengos, Karla Bonic, Florian Goncalves, Xin Yi, Michael I. Henderson, Srivathsan Ranganathan, Bruce P. Branchaud, Leslie L. Muldoon, Ramon F. Barajas Jr, Jared M. Fischer, Adem Yildirim   +19 more
wiley   +1 more source

A Dual‐Locking G‐Quadruplex DNA Targeting Strategy Based on a Tumor‐Accumulating Porphyrin‐Ruthenium(II) Conjugate for Type I Photodynamic Therapy

Aggregate, Volume 7, Issue 1, January 2026.
This study identifies PorRu as a “dual‐lock” G‐quadruplex binder, which also serves as a tumor‐targeting Type I photosensitizer. This agent overcomes the limitations of oxygen‐dependent PDT, providing a novel strategy for precise HCC therapy. ABSTRACT The hypoxic tumor microenvironment severely limits the effectiveness of photodynamic therapy (PDT) in ...
Qiong Wu, Wan‐Wan Hong, Jia‐Hui Shi, Ren‐Shan Deng, Wan‐Qi Chen, Chan‐Ling Yuan, Wen‐Jie Mei   +6 more
wiley   +1 more source

Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids [PDF]

, 2012
Over eight different families of natural products, consisting of nearly seventy secondary metabolites, which contain the bicyclo[2.2.2]diazaoctane ring system, have been isolated from various Aspergillus, Penicillium, and Malbranchea species. Since 1968,
Antia B. S., Arai K., Baldas J., Banks R. M., Banks R. M., Birch A. J., Birch A. J., Birch A. J., Blanchflower S. E., Blanchflower S. E., Boysen M., Byung H. L., Capon R. J., Chu Y.-S., David H. Sherman, Davies J., Ding Y., Ding Y., Ding Y., Domingo L. R., Figueroa M., Figueroa M., Finefield J. M., Frisvad J. C., Frisvad J. C., Frisvad J. C., Frisvad J. C., Frisvad J. C., Frisvad J. C., Frisvad J. C., Gray C. R., Greshock T. J., Greshock T. J., Greshock T. J., Greshock T. J., Grubbs A. W., Guo J.-P., Hayashi H., Hayashi H., Houbraken J., Houbraken J., Houbraken J., Houbraken J., Houbraken J., Jennifer M. Finefield, Jens C. Frisvad, Kaminsky R., Kato H., Kito K., Kuo M. S., Kuo M. S., Kushida N., Lee B. H., Liesch J. M., Lin Z., Little P. R., Lopez-Gresa M. P., Love S., Martínez-Luis S., Marínez-Luis S., McAfoos T. J., Miller K. A., Miller K. A., Miller K. A., Miller K. A., Mugishima T., Myers A. G., Nielsen K. F., Nielsen K. F., Nielsen K. F., Noonim P., Ondeyka J. G., Ostlind D. A., O’Brien M., Pareniková L., Paterson R. R. M., Paterson R. R. M., Perrone G., Pitt J. I., Polonsky J., Porter A. E. A., Prangé T., Qian-Cutrone J., Raper K. B., Raper K. B., Robbers J. E., Robert M. Williams, Samson R. A., Samson R. A., Samson R. A., Samson R. A., Sanz-Cervera J. F., Scott P. M., Shoop W. L., Steyn P. S., Steyn P. S., Steyn P. S., Stocking E. M., Stocking E. M., Stocking E. M., Stocking E. M., Stocking E. M., Stocking E. M., Stocking E. M., Sugie Y., Sunderhaus J. D., Sørensen A., Tsuda M., Tsukamoto S., Tsukamoto S., Tsukamoto S., Tsukamoto S., Tuthill D. E., Varga J., Watts K. R., Whyte A. C., Williams R. M., Williams R. M., Williams R. M., Williams R. M., Wilson B. J., Wulff J. E., Yamazaki M., Zhang D., Zinser E. W.   +124 more
core   +1 more source

Anion‐π+ Type AIE‐Active Photosensitizers for Ferroptosis‐Driven Photodynamic Immunotherapy Against Hypoxic Solid Tumors

Aggregate, Volume 7, Issue 1, January 2026.
An anion‐π+ type AIE photosensitizer (TMTPA NPs) with NIR emission was successfully developed through a sulfidation strategy. With its exceptional mitochondrial targeting abilities and efficient Type I ROS generation, TMTPA NPs effectively trigger ferroptosis.
Lingxiu Liu, Jianye Gong, Xue Wang, Ying Zhang, Guoyu Jiang, Jianguo Wang, Ben Zhong Tang   +6 more
wiley   +1 more source