Results 21 to 30 of about 186,134 (269)

High-Resolution Histological Landscape of AAV DNA Distribution in Cellular Compartments and Tissues following Local and Systemic Injection

Molecular Therapy: Methods & Clinical Development, 2020
Adeno-associated virus (AAV) is one of the most important gene delivery vehicles for in vivo gene therapy. Intramuscular (i.m.) and intravascular (i.v.) injection are commonly used for AAV gene transfer.
Junling Zhao, Yongping Yue, Aman Patel, Lakmini Wasala, Jacob F. Karp, Keqing Zhang, Dongsheng Duan, Yi Lai   +7 more
doaj   +1 more source

Comparing implantable epimysial and intramuscular electrodes for prosthetic control

Frontiers in Neuroscience
IntroductionImplantable electrodes are the subject of increasing interest due to the possibilities they present for the control of assistive devices such as prosthetic limbs, however evidence as to whether epimysial or intramuscular electrodes result in ...
Eric J. Earley, Eric J. Earley, Eric J. Earley, Eric J. Earley, Morten B. Kristoffersen, Morten B. Kristoffersen, Max Ortiz-Catalan, Max Ortiz-Catalan, Max Ortiz-Catalan   +8 more
doaj   +1 more source

A misplaced intramuscular injection and limb-threatening ischemia

Journal of Family Medicine and Primary Care, 2017
Femoral artery thrombosis is a rare complication of intramuscular (IM) injection in children. A 12-month-old boy presented with right lower limb ischemia and digital gangrene 3 days after an injection of ceftriaxone administered to his medial aspect of ...
Sumantra Sarkar, Sarbani Misra, Madhumita Nandi, Rakesh Mondal   +3 more
doaj   +1 more source

Use of goat interleukin-6, cortisol, and some biomarkers to evaluate clinical suitability of two routes of ascorbic acid administration in transportation stress [PDF]

Veterinary World, 2018
Aim: The study determined the effect of ascorbic acid (administered orally and intramuscularly) in short-term transportation stress. Materials and Methods: Twenty-four apparently healthy Kalahari goats were grouped into four groups (A, B, C, and D) of
K. T. Biobaku, T. O. Omobowale, Ahmed O. Akeem, A. Aremu, N. Okwelum, A. S. Adah   +5 more
doaj   +1 more source

How Safe Are Oxygen–Ozone Therapy Procedures for Spine Disc Herniation? The SIOOT Protocols for Treating Spine Disorders

Journal of Imaging
Oxygen–ozone (O2–O3) therapy is widely used for treating lumbar disc herniation. However, controversy remains regarding the safest and most effective route of administration. While intradiscal injection is purported to show clinical efficacy, it has also
Marianno Franzini, Salvatore Chirumbolo, Francesco Vaiano, Luigi Valdenassi, Francesca Giannetti, Marianna Chierchia, Umberto Tirelli, Paolo Bonacina, Gianluca Poggi, Aniello Langella, Edoardo Maria Pieracci, Christian Giannetti, Roberto Antonio Giannetti   +12 more
doaj   +1 more source

Transcriptome and Cellular Evidence of Depot-Specific Function in Beef Cattle Intramuscular, Subcutaneous, and Visceral Adipose Tissues

Biology
Deposition of intramuscular adipose tissue (IMAT) is the primary determinant for beef quality grade in the U.S. Accumulation of subcutaneous (SCAT) and visceral (VIAT) adipose tissue precedes that of IMAT and often leads to excessive adiposity in beef ...
Alexandra P. Tegeler, Hunter R. Ford, Jean Franco Fiallo-Diez, Tainara C. Michelotti, Bradley J. Johnson, Oscar J. Benitez, Dale R. Woerner, Clarissa Strieder-Barboza   +7 more
doaj   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source