Results 161 to 170 of about 109,887 (251)

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, EarlyView.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

Applications of chitosan derivatives as adjuvants for nanoparticle‐based vaccines: A comprehensive review

Smart Molecules, EarlyView.
This review highlights how chitosan derivatives enhance nanoparticle‐based vaccines through superior stability, mucoadhesion, and immune modulation. By triggering robust mucosal, humoral, and cellular responses, these biocompatible polymers serve as a transformative platform for next‐generation immunotherapeutics and safe and effective vaccine delivery
Sayantani Dasgupta, Susanta Paul, Swarupananda Mukherjee, Nilanjan Sarkar, Arvind Kumar, Amrita Chakraborty, Anannya Bose, Atanu Hazra, Mainak Chakraborty   +8 more
wiley   +1 more source

Could Flumazenil Be Used Pre-hospital by Intramuscular Injection for Coma due to Mixed Drug Overdose Not Responding to Naloxone?: A Systematic Review of the Evidence. [PDF]

Basic Clin Pharmacol Toxicol
Farcas I, Schölin L, Eddleston M.
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

A Double-Blind Randomized Active-Controlled Trial Evaluating the Short-Term Efficacy of a Single Intramuscular Injection of a Fixed-Dose Combination Product Containing Diclofenac and Thiocolchicoside in Patients with Acute Moderate to Severe Low Back Pain. [PDF]

J Clin Med
Oikonomou I, Panagiotopoulou M, Christopoulos N, Loukeri E, Christodoulakis G, Kountis G, Papadakis SA, Chiotis I, Georgokostas A, Garantziotis N, Loukas C, Pallis D, Nikolakakos P, Bassiakos YC.   +13 more
europepmc   +1 more source

Injectable Zein‐Based Photothermal Composite Hydrogel Enhances Osteoporotic Tendon–Bone Healing

Small Methods, EarlyView.
Schematic illustration of the Zein‐based, dopamine‐grafted, niacin‐loaded carbon nanosphere (ZDC) composite hydrogel for enhancing healing of osteoporotic rotator cuff tears. This electron beam‐modified composite hydrogel is designed for NIR‐responsive release of niacin, which alleviates inflammation, promotes angiogenesis, and facilitates the ...
Kai Ye, Peng Ding, Zhenyou Dong, Wenyan Shi, Longxiang Shen, Xianyou Zheng   +5 more
wiley   +1 more source

Population pharmacokinetics of rilpivirine following oral administration and long-acting intramuscular injection in real-world people with HIV. [PDF]

Front Pharmacol
Thoueille P, Saldanha SA, Schaller F, Choong E, Veuve F, Munting A, Cavassini M, Braun D, Günthard HF, Duran Ramirez JJ, Surial B, Furrer H, Rauch A, Ustero P, Calmy A, Stöckle M, Di Benedetto C, Bernasconi E, Schmid P, Marzolini C, Girardin FR, Buclin T, Decosterd LA, Guidi M.   +23 more
europepmc   +1 more source

Interspecific Differences in the Effects on Embryos Between Freshwater and Marine Fish Exposed to Water‐Accommodated Fractions Derived From Very‐Low Sulfur Fuel Oil

Environmental Toxicology, EarlyView.
ABSTRACT This study evaluated the toxic effects of water‐accommodated fractions (WAFs) of very‐low sulfur fuel oil (VLSFO) on freshwater and marine fish embryos. Embryos of Japanese medaka (Oryzias latipes), Java medaka (Oryzias javanicus), and grass puffer (Takifugu alboplumbeus) were exposed to various concentrations of VLSFO‐WAF, and the effects on ...
Jumpei Matsuo, Shusaku Fukugami, Kei Nakayama, Masatoshi Yamasaki, Emiko Kokushi, Seiichi Uno   +5 more
wiley   +1 more source

Comparison of the effect of intramuscular injection from two different sites on pain and fear in children: a randomized controlled study. [PDF]

Rev Assoc Med Bras (1992)
Tiryaki Ö, Menekşe D, Özdemir Ö, Çınar N, Elmas B.   +4 more
europepmc   +1 more source