Results 51 to 60 of about 177,118 (275)

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation reduces the development of long-term muscle pain [PDF]

, 2018
The left dorsolateral prefrontal cortex (DLPFC) is involved in the experience and modulation of pain, and may be an important node linking pain and cognition.
De Martino, Enrico, Graven-Nielsen, Thomas, Schabrun, Siobhan M., Seminowicz, David A.   +3 more
core   +3 more sources

Evaluation of an Applied Method in Reducing the Pain of Intramuscular Injection

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2013
Background and Objectives: Injection is one of the most painful and common medical interventions that more than 12 billion of it are administered annually throughout the world. In spite of the wide use of this intervention, its associated pain remains as
Mohammad-Reza Yeganekhah, Zahra Abedini, Tahmine Dadkhah Tehrani   +2 more
doaj  

Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain

Advanced Materials, EarlyView.
A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng, Xiong Wang, Cien Chen, Di Wang, Changshun Hou, Yiran Wang, Huan Hu, Peiran Chen, LeiYing Qin, Qianya Wan, Xi Yao, Ming‐Liang He   +11 more
wiley   +1 more source

Effect of Administration Route on the Pharmacokinetics of Cobalamin in Elderly Patients: A Randomized Controlled Trial

Current Therapeutic Research, 2014
Background: The gold standard for cobalamin deficiency treatment is administration of cobalamin by intramuscular injection. The injection is painful and inconvenient, particularly for elderly persons.
Monique P.H. Tillemans, PharmD, Eline M.V.J. Donders, MD, Sjoerd L. Verweij, PharmD, Ruud T.M. Van der Hoeven, PharmD, Kees J. Kalisvaart, MD, PhD   +4 more
doaj   +1 more source

A Pseudo‐Mytilus Edulis Foot Protein‐Based Hydrogel Adhesive with Osteo‐Vascular‐Immune Coupling Effects for Osteoporotic Bone‐Implant Integration

Advanced Materials, EarlyView.
Inspired by mussel proteins, YDC‐Gel‐Zn is a smart bone glue designed for osteoporotic implants. It adheres strongly to both metal implants and bone for initial fixation. In osteoporosis's inflammatory environment, it sequentially releases zinc ions and therapeutic peptides: the zinc modulates immune cells to reduce inflammation, while the peptides ...
Wentao Wang, Zhenyu Li, Siming Zhang, Yue Ma, Lei Yu, Qidong Zhang, Guoqing Pan, Dechun Geng, Chen Zhu, Jiaxiang Bai   +9 more
wiley   +1 more source

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]

, 2012
Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core   +1 more source

Nicolau Syndrome after Intramuscular Benzathine Penicillin Injection

Iranian Journal of Medical Sciences, 2014
A 3-year-old boy was admitted to the emergency department with right lower limb pain, edema, and livedoid discoloration that occurred immediately after intramuscular injection of benzathine penicillin.
Morteza Noaparast, Rasoul Mirsharifi, Fezzeh Elyasinia, Reza Parsaei, Hessam Kondori, Sara Farifteh   +5 more
doaj  

A double-blinded prospective randomized control study of preoperative administration of intravenous mephentermine vs intramuscular mephentermine in preventing post-spinal hypotension in caesarean section

Journal of Obstetric Anaesthesia and Critical Care
Context: Mephentermine by intramuscular route prevents post-spinal anesthesia hypotension. However, the intravenous route had not been tried earlier for this prophylactic purpose.
Sagnik Datta, Suman Chattopadhyay, Arun K Mandi, Debasish Bhar   +3 more
doaj   +1 more source

RNA-Seq Based Toxicity Analysis of Mesoporous Polydopamine Nanoparticles in Mice Following Different Exposure Routes

Frontiers in Bioengineering and Biotechnology, 2022
Mesoporous polydopamine nanoparticles (MPDA NPs) are promising nanomaterials that have the prospect of clinical application for multi-strategy antitumor therapy, while the biosecurity of MPDA NPs remains indistinct.
Zihua Huang, Luoyijun Xie, Jifan Zhang, Qiyan Li, Yulin Liu, Xuemei Fu, Miaomiao Yuan, Qingjiao Li   +7 more
doaj   +1 more source